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Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam

Author

Listed:
  • La Thi Quynh Lien

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden
    Department of Pharmaceutical Management and Pharmaco-Economics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem District, Hanoi 110403, Vietnam)

  • Pham Thi Lan

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam)

  • Nguyen Thi Kim Chuc

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam)

  • Nguyen Quynh Hoa

    (National Centralized Drug Procurement Centre, Vietnam Ministry of Health, 138A Giang Vo Street, Ba Dinh district, Hanoi 118401, Vietnam)

  • Pham Hong Nhung

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam
    Department of Microbiology, Bach Mai Hospital, 78 Giai Phong, Dong Da District, Hanoi 116365, Vietnam)

  • Nguyen Thi Minh Thoa

    (Department of Dermatology and Venereology, Department of Family Medicine, Department of Microbiology, Hanoi Medical University, 01 Ton That Tung, Dong Da District, Hanoi 116516, Vietnam)

  • Vishal Diwan

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden
    Department of Public Health & Environment, R.D. Gardi Medical College, Agar Road, Ujjain 456006, India)

  • Ashok J. Tamhankar

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden
    Indian Initiative for Management of Antibiotic Resistance, Department of Environmental Medicine, R.D. Gardi Medical College, Agar Road, Ujjain 456006, India)

  • Cecilia Stålsby Lundborg

    (Health Systems and Policy (HSP): Improving the Use of Medicines, Department of Public Health Sciences, Karolinska Institutet, Tomtebodavägen 18A, 17177 Stockholm, Sweden)

Abstract

The environmental spread of antibiotic-resistant bacteria has been recognised as a growing public health threat for which hospitals play a significant role. The aims of this study were to investigate the prevalence of antibiotic resistance and antibiotic resistance genes (ARGs) in Escherichia coli isolates from hospital wastewater in Vietnam. Wastewater samples before and after treatment were collected using continuous sampling every month over a year. Standard disk diffusion and E-test were used for antibiotic susceptibility testing. Extended-spectrum beta-lactamase (ESBL) production was tested using combined disk diffusion. ARGs were detected by polymerase chain reactions. Resistance to at least one antibiotic was detected in 83% of isolates; multidrug resistance was found in 32%. The highest resistance prevalence was found for co-trimoxazole (70%) and the lowest for imipenem (1%). Forty-three percent of isolates were ESBL-producing, with the bla TEM gene being more common than bla CTX-M . Co-harbouring of the bla CTX-M , bla TEM and qepA genes was found in 46% of isolates resistant to ciprofloxacin. The large presence of antibiotic-resistant E. coli isolates combined with ARGs in hospital wastewater, even post-treatment, poses a threat to public health. It highlights the need to develop effective processes for hospital wastewater treatment plants to eliminate antibiotic resistant bacteria and ARGs.

Suggested Citation

  • La Thi Quynh Lien & Pham Thi Lan & Nguyen Thi Kim Chuc & Nguyen Quynh Hoa & Pham Hong Nhung & Nguyen Thi Minh Thoa & Vishal Diwan & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2017. "Antibiotic Resistance and Antibiotic Resistance Genes in Escherichia coli Isolates from Hospital Wastewater in Vietnam," IJERPH, MDPI, vol. 14(7), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:7:p:699-:d:103092
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    References listed on IDEAS

    as
    1. Benson Chuks Iweriebor & Sisipho Gaqavu & Larry Chikwelu Obi & Uchechukwu U. Nwodo & Anthony I. Okoh, 2015. "Antibiotic Susceptibilities of Enterococcus Species Isolated from Hospital and Domestic Wastewater Effluents in Alice, Eastern Cape Province of South Africa," IJERPH, MDPI, vol. 12(4), pages 1-16, April.
    2. La Thi Quynh Lien & Nguyen Quynh Hoa & Nguyen Thi Kim Chuc & Nguyen Thi Minh Thoa & Ho Dang Phuc & Vishal Diwan & Nguyen Thanh Dat & Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2016. "Antibiotics in Wastewater of a Rural and an Urban Hospital before and after Wastewater Treatment, and the Relationship with Antibiotic Use—A One Year Study from Vietnam," IJERPH, MDPI, vol. 13(6), pages 1-13, June.
    3. Roseann Velez & Elizabeth Sloand, 2016. "Combating antibiotic resistance, mitigating future threats and ongoing initiatives," Journal of Clinical Nursing, John Wiley & Sons, vol. 25(13-14), pages 1886-1889, July.
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    Cited by:

    1. Ashok J. Tamhankar & Cecilia Stålsby Lundborg, 2019. "Antimicrobials and Antimicrobial Resistance in the Environment and Its Remediation: A Global One Health Perspective," IJERPH, MDPI, vol. 16(23), pages 1-7, November.
    2. Thérèse Krahnstöver & Naiara Santos & Karyn Georges & Luiza Campos & Blanca Antizar-Ladislao, 2022. "Low-Carbon Technologies to Remove Organic Micropollutants from Wastewater: A Focus on Pharmaceuticals," Sustainability, MDPI, vol. 14(18), pages 1-26, September.
    3. Amarachukwu Obayiuwana & Adeniyi Ogunjobi & Min Yang & Mark Ibekwe, 2018. "Characterization of Bacterial Communities and Their Antibiotic Resistance Profiles in Wastewaters Obtained from Pharmaceutical Facilities in Lagos and Ogun States, Nigeria," IJERPH, MDPI, vol. 15(7), pages 1-14, June.

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