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Association of Long-Term Near-Highway Exposure to Ultrafine Particles with Cardiovascular Diseases, Diabetes and Hypertension

Author

Listed:
  • Yu Li

    (Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA)

  • Kevin J. Lane

    (Yale School of Forestry and Environmental Studies, Yale University, New Haven, CT 06511, USA
    Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA)

  • Laura Corlin

    (Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA)

  • Allison P. Patton

    (Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA
    Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA)

  • John L. Durant

    (Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA)

  • Mohan Thanikachalam

    (Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USA)

  • Mark Woodin

    (Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA)

  • Molin Wang

    (Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA)

  • Doug Brugge

    (Department of Civil and Environmental Engineering, Tufts University, Medford, MA 02155, USA
    Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Jonathan M. Tisch College of Civic Life, Tufts University, Medford, MA 02155, USA)

Abstract

Ultrafine particle (UFP) concentrations are elevated near busy roadways, however, their effects on prevalence of cardiovascular diseases, diabetes, and hypertension are not well understood. To investigate these associations, data on demographics, diseases, medication use, and time of activities were collected by in-home surveys for 704 participants in three pairs of near-highway and urban background neighborhoods in and near Boston (MA, USA). Body mass index (BMI) was measured for a subset of 435 participants. Particle number concentration (PNC, a measure of UFP) was collected by mobile monitoring in each area. Intra-neighborhood spatial-temporal regression models (approximately 20 m resolution) were used to estimate hourly ambient PNC at the residences of participants. We used participant time activity information to adjust annual average residential PNC values and assign individualized time activity adjusted annual average PNC exposures (TAA-PNC). Using multivariate logistic regression models, we found an odds ratio (OR) of 1.35 (95% CI: 0.83, 2.22) of TAA-PNC with stroke and ischemic heart diseases (S/IHD), an OR of 1.14 (95% CI: 0.81, 1.62) with hypertension, and an OR of 0.71 (95% CI: 0.46, 1.10) for diabetes. A subset analysis controlling for BMI produced slightly stronger associations for S/IHD (OR = 1.61, 95% CI: 0.88, 2.92) and hypertension (OR = 1.28, 95% CI: 0.81, 2.02), and no association with diabetes (OR = 1.09, 95% CI = 0.61, 1.96). Further research is needed with larger sample sizes and longitudinal follow-up.

Suggested Citation

  • Yu Li & Kevin J. Lane & Laura Corlin & Allison P. Patton & John L. Durant & Mohan Thanikachalam & Mark Woodin & Molin Wang & Doug Brugge, 2017. "Association of Long-Term Near-Highway Exposure to Ultrafine Particles with Cardiovascular Diseases, Diabetes and Hypertension," IJERPH, MDPI, vol. 14(5), pages 1-16, April.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:5:p:461-:d:96843
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    References listed on IDEAS

    as
    1. Mei Chung & Ding Ding Wang & Amanda M. Rizzo & Darrel Gachette & Marie Delnord & Ron Parambi & Choong-Min Kang & Doug Brugge, 2015. "Association of PNC, BC, and PM 2.5 Measured at a Central Monitoring Site with Blood Pressure in a Predominantly Near Highway Population," IJERPH, MDPI, vol. 12(3), pages 1-16, March.
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    Cited by:

    1. Laura Corlin & Shannon Ball & Mark Woodin & Allison P. Patton & Kevin Lane & John L. Durant & Doug Brugge, 2018. "Relationship of Time-Activity-Adjusted Particle Number Concentration with Blood Pressure," IJERPH, MDPI, vol. 15(9), pages 1-20, September.
    2. Vesna Viher Hrženjak & Andreja Kukec & Ivan Eržen & Dalibor Stanimirović, 2020. "Effects of Ultrafine Particles in Ambient Air on Primary Health Care Consultations for Diabetes in Children and Elderly Population in Ljubljana, Slovenia: A 5-Year Time-Trend Study," IJERPH, MDPI, vol. 17(14), pages 1-19, July.
    3. Barouch Giechaskiel & Tero Lähde & Sawan Gandi & Stefan Keller & Philipp Kreutziger & Athanasios Mamakos, 2020. "Assessment of 10-nm Particle Number (PN) Portable Emissions Measurement Systems (PEMS) for Future Regulations," IJERPH, MDPI, vol. 17(11), pages 1-16, May.
    4. Barouch Giechaskiel, 2018. "Solid Particle Number Emission Factors of Euro VI Heavy-Duty Vehicles on the Road and in the Laboratory," IJERPH, MDPI, vol. 15(2), pages 1-24, February.
    5. Bindu Panikkar & Qing Ren & Fosca Bechthold, 2023. "Transportation Justice in Vermont Communities of High Environmental Risk," Sustainability, MDPI, vol. 15(3), pages 1-18, January.

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