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Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women

Author

Listed:
  • Osmel La-Llave-León

    (Institute of Scientific Research, Juarez University of the State of Durango, AV. Universidad y Fanny Anitua s/n. Col. Centro, C. P. 34000 Durango, Mexico)

  • Edna M. Méndez-Hernández

    (Institute of Scientific Research, Juarez University of the State of Durango, AV. Universidad y Fanny Anitua s/n. Col. Centro, C. P. 34000 Durango, Mexico)

  • Francisco X. Castellanos-Juárez

    (Institute of Scientific Research, Juarez University of the State of Durango, AV. Universidad y Fanny Anitua s/n. Col. Centro, C. P. 34000 Durango, Mexico)

  • Eloísa Esquivel-Rodríguez

    (Faculty of Nursing and Midwifery, Juarez University of the State of Durango, Cuauhtemoc, 223 North, Col. Centro, C. P. 34000 Durango, Mexico)

  • Fernando Vázquez-Alaniz

    (General Hospital 450, Health Services, C. P. 34000 Durango, Mexico)

  • Ada Sandoval-Carrillo

    (Institute of Scientific Research, Juarez University of the State of Durango, AV. Universidad y Fanny Anitua s/n. Col. Centro, C. P. 34000 Durango, Mexico)

  • Gonzalo García-Vargas

    (Faculty of Health Sciences, Juarez University of the State of Durango, Gomez Palacio la Salle 1 y Sixto Ugalde, s/n, Col. Revolucion, C. P. 35050 Gomez Palacio, Durango, Mexico)

  • Jaime Duarte-Sustaita

    (Faculty of Health Sciences, Juarez University of the State of Durango, Gomez Palacio la Salle 1 y Sixto Ugalde, s/n, Col. Revolucion, C. P. 35050 Gomez Palacio, Durango, Mexico)

  • Jorge L. Candelas-Rangel

    (Faculty of Health Sciences, Juarez University of the State of Durango, Gomez Palacio la Salle 1 y Sixto Ugalde, s/n, Col. Revolucion, C. P. 35050 Gomez Palacio, Durango, Mexico)

  • José M. Salas-Pacheco

    (Institute of Scientific Research, Juarez University of the State of Durango, AV. Universidad y Fanny Anitua s/n. Col. Centro, C. P. 34000 Durango, Mexico)

Abstract

Blood lead levels (BLLs) and delta-aminolevulinic acid dehydratase (ALAD) activity are considered biomarkers of lead exposure and lead toxicity, respectively. The present study was designed to investigate the association between BLLs and ALAD activity in pregnant women from Durango, Mexico. A total of 633 pregnant women aged 13–43 years participated in this study. Blood lead was measured by a graphite furnace atomic absorption spectrometer. ALAD activity was measured spectrophotometrically. Mean blood lead was 2.09 ± 2.34 µg/dL; and 26 women (4.1%) crossed the Centers for Disease Control (CDC) recommended level of 5 µg/dL. ALAD activity was significantly lower in women with levels of lead ≥5 µg/dL compared to those with BLLs < 5 µg/dL ( p = 0.002). To reduce the influence of extreme values on the statistical analysis, BLLs were analyzed by quartiles. A significant negative correlation between blood lead and ALAD activity was observed in the fourth quartile of BLLs (r = −0.113; p < 0.01). Among women with blood lead concentrations ≥2.2 µg/dL ALAD activity was negatively correlated with BLLs (r = −0.413; p < 0.01). Multiple linear regression demonstrated that inhibition of ALAD in pregnant women may occur at levels of lead in blood above 2.2 µg/dL.

Suggested Citation

  • Osmel La-Llave-León & Edna M. Méndez-Hernández & Francisco X. Castellanos-Juárez & Eloísa Esquivel-Rodríguez & Fernando Vázquez-Alaniz & Ada Sandoval-Carrillo & Gonzalo García-Vargas & Jaime Duarte-Su, 2017. "Association between Blood Lead Levels and Delta-Aminolevulinic Acid Dehydratase in Pregnant Women," IJERPH, MDPI, vol. 14(4), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:4:p:432-:d:96083
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    References listed on IDEAS

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    1. Sabrina Nunes do Nascimento & Mariele Feiffer Charão & Angela Maria Moro & Miguel Roehrs & Clovis Paniz & Marília Baierle & Natália Brucker & Adriana Gioda & Fernando Barbosa & Denise Bohrer & Daiana , 2014. "Evaluation of Toxic Metals and Essential Elements in Children with Learning Disabilities from a Rural Area of Southern Brazil," IJERPH, MDPI, vol. 11(10), pages 1-18, October.
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    Cited by:

    1. Chan-Ching Huang & Chen-Cheng Yang & Te-Yu Liu & Chia-Yen Dai & Chao-Ling Wang & Hung-Yi Chuang, 2020. "Use of Generalized Additive Model to Detect the Threshold of δ-Aminolevulinic Acid Dehydratase Activity Reduced by Lead Exposure," IJERPH, MDPI, vol. 17(16), pages 1-10, August.
    2. Homègnon A. Ferréol Bah & Victor O. Martinez & Nathália R. dos Santos & Erival A. Gomes Junior & Daisy O. Costa & Elis Macêdo Pires & João V. Araújo Santana & Filipe da Silva Cerqueira & José A. Menez, 2023. "Determinants of Exposure to Potentially Toxic Metals in Pregnant Women of the DSAN-12M Cohort in the Recôncavo Baiano, Brazil," IJERPH, MDPI, vol. 20(4), pages 1-16, February.

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