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Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview

Author

Listed:
  • Virginia Andreoli

    (Institute of Atmospheric Pollution Research, National Research Council of Italy, Division of Rende, Rende 87036, Italy)

  • Francesca Sprovieri

    (Institute of Atmospheric Pollution Research, National Research Council of Italy, Division of Rende, Rende 87036, Italy)

Abstract

Human exposure to mercury is still a major public health concern. In this context, children have a higher susceptibility to adverse neurological mercury effects, compared to adults with similar exposures. Moreover, there exists a marked variability of personal response to detrimental mercury action, in particular among population groups with significant mercury exposure. New scientific evidence on genetic backgrounds has raised the issue of whether candidate susceptibility genes can make certain individuals more or less vulnerable to mercury toxicity. In this review, the aim is to evaluate a new genetic dimension and its involvement in mercury risk assessment, focusing on the important role played by relevant polymorphisms, located in attractive gene targets for mercury toxicity. Existing original articles on epidemiologic research which report a direct link between the genetic basis of personal vulnerability and different mercury repercussions on human health will be reviewed. Based on this evidence, a careful evaluation of the significant markers of susceptibility will be suggested, in order to obtain a powerful positive “feedback” to improve the quality of life. Large consortia of studies with clear phenotypic assessments will help clarify the “window of susceptibility” in the human health risks due to mercury exposure.

Suggested Citation

  • Virginia Andreoli & Francesca Sprovieri, 2017. "Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview," IJERPH, MDPI, vol. 14(1), pages 1-25, January.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:1:p:93-:d:88184
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    Citations

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    Cited by:

    1. Halina Pyta & Kamila Widziewicz-Rzońca & Krzysztof Słaby, 2020. "Inhalation Exposure to Gaseous and Particulate Bound Mercury Present in the Ambient Air over the Polluted Area of Southern Poland," IJERPH, MDPI, vol. 17(14), pages 1-17, July.
    2. Jamila Alessandra Perini & Mayara Calixto Silva & Ana Claudia Santiago de Vasconcellos & Paulo Victor Sousa Viana & Marcelo Oliveira Lima & Iracina Maura Jesus & Joseph William Kempton & Rogério Adas , 2021. "Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase ( ALAD ) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    3. Barbara Brodziak-Dopierała & Agnieszka Fischer, 2022. "Analysis of Mercury Content in Various Types of Tea ( Camellia sinensis ) and Yerba Mate ( Ilex paraguariensis )," IJERPH, MDPI, vol. 19(9), pages 1-11, May.
    4. Barbara Brodziak-Dopierała & Agnieszka Fischer & Martyna Chrzanowska & Bożena Ahnert, 2023. "Mercury Exposure from the Consumption of Dietary Supplements Containing Vegetable, Cod Liver, and Shark Liver Oils," IJERPH, MDPI, vol. 20(3), pages 1-14, January.
    5. Roger Pamphlett & Andrew J. Colebatch & Philip A. Doble & David P. Bishop, 2020. "Mercury in Pancreatic Cells of People with and without Pancreatic Cancer," IJERPH, MDPI, vol. 17(23), pages 1-16, December.
    6. Sonia Mireya Díaz & Maria Nathalia Muñoz-Guerrero & Marien Palma-Parra & Carolina Becerra-Arias & Julián Alfredo Fernández-Niño, 2018. "Exposure to Mercury in Workers and the Population Surrounding Gold Mining Areas in the Mojana Region, Colombia," IJERPH, MDPI, vol. 15(11), pages 1-15, October.
    7. Uchenna Okereafor & Mamookho Makhatha & Lukhanyo Mekuto & Nkemdinma Uche-Okereafor & Tendani Sebola & Vuyo Mavumengwana, 2020. "Toxic Metal Implications on Agricultural Soils, Plants, Animals, Aquatic life and Human Health," IJERPH, MDPI, vol. 17(7), pages 1-24, March.
    8. Jane A. Parkin Kullmann & Roger Pamphlett, 2018. "A Comparison of Mercury Exposure from Seafood Consumption and Dental Amalgam Fillings in People with and without Amyotrophic Lateral Sclerosis (ALS): An International Online Case-Control Study," IJERPH, MDPI, vol. 15(12), pages 1-14, December.

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