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Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents

Author

Listed:
  • Dong Xu

    (National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China
    These authors contributed equally to this work.)

  • Qingyun Wang

    (National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China
    These authors contributed equally to this work.)

  • Tao Yang

    (National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China)

  • Jianzhong Cao

    (National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China)

  • Qinlu Lin

    (National Engineering Laboratory for Rice and By-Products Further Processing, Central South University of Forestry & Technology, Changsha 410004, China)

  • Zhiqin Yuan

    (State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China)

  • Le Li

    (Hunan Ehome Health Technology Inc., Buliding 6# 1715, LvDi Central Square, Yuelu District, Changsha 410023, China)

Abstract

Development of efficient antibacterial agents is critical for human health. In the present study, we investigated the antibacterial activity of polyethyleneimine (PEI)-capped silver nanoclusters (PEI-AgNCs), based on the fact that nanoclusters normally have higher surface-to-volume ratios than traditional nanomaterials and PEI itself has a strong antimicrobial capacity. We synthesized stable silver nanoclusters by altering PEI molecular weight from 0.6 kDa to 25 kDa and characterized them by UV-Vis absorption and fluorescence spectroscopy and high resolution transmission electron microscopy. The sizes of AgNCs were around 2 nm in diameter and were little influenced by the molecular weight of PEIs. The antibacterial abilities of the four PEI-AgNCs were explored on agar plate and in liquid systems. Our results revealed that the antibacterial activity of PEI-AgNCs is excellent and the reduction of PEI molecular weight could result in the increased antibacterial capacity of PEI-AgNCs. Such proposed new materials might be useful as efficient antibacterial agents in practical clinical applications.

Suggested Citation

  • Dong Xu & Qingyun Wang & Tao Yang & Jianzhong Cao & Qinlu Lin & Zhiqin Yuan & Le Li, 2016. "Polyethyleneimine Capped Silver Nanoclusters as Efficient Antibacterial Agents," IJERPH, MDPI, vol. 13(3), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:3:p:334-:d:66072
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    References listed on IDEAS

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    1. Robert D. Wojtyczka & Kamila Orlewska & Małgorzata Kępa & Danuta Idzik & Arkadiusz Dziedzic & Tomasz Mularz & Michał Krawczyk & Maria Miklasińska & Tomasz J. Wąsik, 2014. "Biofilm Formation and Antimicrobial Susceptibility of Staphylococcus epidermidis Strains from a Hospital Environment," IJERPH, MDPI, vol. 11(5), pages 1-15, April.
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    Cited by:

    1. Meiqing Zhu & Lijun Wang & Yu Wang & Jie Zhou & Jie Ding & Wei Li & Yue Xin & Shisuo Fan & Zhen Wang & Yi Wang, 2018. "Biointeractions of Herbicide Atrazine with Human Serum Albumin: UV-Vis, Fluorescence and Circular Dichroism Approaches," IJERPH, MDPI, vol. 15(1), pages 1-16, January.

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