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Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis

Author

Listed:
  • Hui Shen

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
    These authors contributed equally to this work.)

  • Qiang Niu

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Mengchuan Xu

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Dongsheng Rui

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Shangzhi Xu

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Gangling Feng

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Yusong Ding

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Shugang Li

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

  • Mingxia Jing

    (Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China)

Abstract

Chronic arsenic exposure is a critical public health issue in many countries. The metabolism of arsenic in vivo is complicated because it can be influenced by many factors. In the present meta-analysis, two researchers independently searched electronic databases, including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze factors influencing arsenic methylation. The concentrations of the following arsenic metabolites increase ( p < 0.000001) following arsenic exposure: inorganic arsenic (iAs), monomethyl arsenic (MMA), dimethyl arsenic (DMA), and total arsenic. Additionally, the percentages of iAs (standard mean difference (SMD): 1.00; 95% confidence interval (CI): 0.60–1.40; p < 0.00001) and MMA (SMD: 0.49; 95% CI: 0.21–0.77; p = 0.0006) also increase, while the percentage of DMA (SMD: −0.57; 95% CI: −0.80–−0.31; p < 0.0001), primary methylation index (SMD: −0.57; 95% CI: −0.94–−0.20; p = 0.002), and secondary methylation index (SMD: −0.27; 95% CI: −0.46–−0.90; p = 0.004) decrease. Smoking, drinking, and older age can reduce arsenic methylation, and arsenic methylation is more efficient in women than in men. The results of this analysis may provide information regarding the role of arsenic oxidative methylation in the arsenic poisoning process.

Suggested Citation

  • Hui Shen & Qiang Niu & Mengchuan Xu & Dongsheng Rui & Shangzhi Xu & Gangling Feng & Yusong Ding & Shugang Li & Mingxia Jing, 2016. "Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 13(2), pages 1-18, February.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:2:p:205-:d:63623
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    References listed on IDEAS

    as
    1. Qiang Zhang & Yongfang Li & Juan Liu & Da Wang & Quanmei Zheng & Guifan Sun, 2014. "Differences of Urinary Arsenic Metabolites and Methylation Capacity between Individuals with and without Skin Lesions in Inner Mongolia, Northern China," IJERPH, MDPI, vol. 11(7), pages 1-14, July.
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    Cited by:

    1. Elisa Bustaffa & Francesca Gorini & Fabrizio Bianchi & Fabrizio Minichilli, 2020. "Factors Affecting Arsenic Methylation in Contaminated Italian Areas," IJERPH, MDPI, vol. 17(14), pages 1-21, July.
    2. Md. Khalequzzaman Sarker & Selim Reza Tony & Abu Eabrahim Siddique & Md. Rezaul Karim & Nazmul Haque & Zohurul Islam & Md. Shofikul Islam & Moriom Khatun & Jahidul Islam & Shakhawoat Hossain & Zahangi, 2021. "Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    3. Pamela Di Giovanni & Giuseppe Di Martino & Piera Scampoli & Fabrizio Cedrone & Francesca Meo & Giuseppe Lucisano & Ferdinando Romano & Tommaso Staniscia, 2020. "Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(9), pages 1-11, April.

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