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Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

Author

Listed:
  • Yazmín Hernández-Díaz

    (División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México)

  • Carlos Alfonso Tovilla-Zárate

    (División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco 86650, México)

  • Isela Juárez-Rojop

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México)

  • María Lilia López-Narváez

    (Hospital General de Yajalón. Secretaría de Salud, Yajalón, Chiapas 29932, México)

  • José Francisco Álvarez-Cámara

    (División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México)

  • Thelma Beatriz González-Castro

    (División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México)

Abstract

Background: The C-reactive protein ( CRP ) and the tumor necrosis factor-alpha ( TNF-α ) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-α genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.

Suggested Citation

  • Yazmín Hernández-Díaz & Carlos Alfonso Tovilla-Zárate & Isela Juárez-Rojop & María Lilia López-Narváez & José Francisco Álvarez-Cámara & Thelma Beatriz González-Castro, 2016. "Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study," IJERPH, MDPI, vol. 13(1), pages 1-8, January.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:1:p:103-:d:61769
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