IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i11p1096-d82389.html
   My bibliography  Save this article

MiRNAs and miRNA Polymorphisms Modify Drug Response

Author

Listed:
  • Mu-Peng Li

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Yao-Dong Hu

    (Department of Cardiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China)

  • Xiao-Lei Hu

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Yan-Jiao Zhang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Yong-Long Yang

    (Haikou People’s Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China)

  • Chun Jiang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Jie Tang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

  • Xiao-Ping Chen

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China)

Abstract

Differences in expression of drug response-related genes contribute to inter-individual variation in drugs’ biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal molecules directly or indirectly. MiRNA polymorphisms, the genetic variations affecting miRNA expression and/or miRNA-mRNA interaction, provide a new insight into the understanding of inter-individual difference in drug response. Here, we provide an overview of the recent progress in miRNAs mediated regulation of biotransformation enzymes, drug transporters, and nuclear receptors. We also describe the implications of miRNA polymorphisms in cancer chemotherapy response.

Suggested Citation

  • Mu-Peng Li & Yao-Dong Hu & Xiao-Lei Hu & Yan-Jiao Zhang & Yong-Long Yang & Chun Jiang & Jie Tang & Xiao-Ping Chen, 2016. "MiRNAs and miRNA Polymorphisms Modify Drug Response," IJERPH, MDPI, vol. 13(11), pages 1-22, November.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1096-:d:82389
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/11/1096/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/11/1096/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Alfons Navarro & Carmen Muñoz & Anna Gaya & Marina Díaz-Beyá & Bernat Gel & Rut Tejero & Tania Díaz & Antonio Martinez & Mariano Monzó, 2013. "MiR-SNPs as Markers of Toxicity and Clinical Outcome in Hodgkin Lymphoma Patients," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    2. Maurizio Marrale & Nadia Ninfa Albanese & Francesco Calì & Valentino Romano, 2014. "Assessing the Impact of Copy Number Variants on miRNA Genes in Autism by Monte Carlo Simulation," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lingzi Xia & Yangwu Ren & Xue Fang & Zhihua Yin & Xuelian Li & Wei Wu & Peng Guan & Baosen Zhou, 2014. "Prognostic Role of Common MicroRNA Polymorphisms in Cancers: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:11:p:1096-:d:82389. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.