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Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

Author

Listed:
  • Gunnar F. Kwakye

    (Neuroscience Department, Oberlin College, Oberlin, OH 44074, USA)

  • Monica M.B. Paoliello

    (Graduate Program in Public Health, Department of Pathology, Clinical and Toxicological Analysis, Center of Health Science, State University of Londrina, Parana 10011, Brazil)

  • Somshuvra Mukhopadhyay

    (Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA)

  • Aaron B. Bowman

    (Department of Neurology and Pediatrics, Vanderbilt University, Nashville, TN 37240, USA)

  • Michael Aschner

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA)

Abstract

Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson’s disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson’s disease (PD).

Suggested Citation

  • Gunnar F. Kwakye & Monica M.B. Paoliello & Somshuvra Mukhopadhyay & Aaron B. Bowman & Michael Aschner, 2015. "Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features," IJERPH, MDPI, vol. 12(7), pages 1-22, July.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:7:p:7519-7540:d:52112
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    References listed on IDEAS

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    1. Hiromi Gunshin & Bryan Mackenzie & Urs V. Berger & Yoshimi Gunshin & Michael F. Romero & Walter F. Boron & Stephan Nussberger & John L. Gollan & Matthias A. Hediger, 1997. "Cloning and characterization of a mammalian proton-coupled metal-ion transporter," Nature, Nature, vol. 388(6641), pages 482-488, July.
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    Cited by:

    1. Airton Cunha Martins & Patricia Morcillo & Omamuyovwi Meashack Ijomone & Vivek Venkataramani & Fiona Edith Harrison & Eunsook Lee & Aaron Blaine Bowman & Michael Aschner, 2019. "New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease," IJERPH, MDPI, vol. 16(19), pages 1-16, September.
    2. Sirisha Nandipati & Irene Litvan, 2016. "Environmental Exposures and Parkinson’s Disease," IJERPH, MDPI, vol. 13(9), pages 1-19, September.
    3. Adi Pinkas & Airton Cunha Martins & Michael Aschner, 2018. "C. elegans —An Emerging Model to Study Metal-Induced RAGE-Related Pathologies," IJERPH, MDPI, vol. 15(7), pages 1-8, July.
    4. Shao-Jun Li & Chao-Yan Ou & Sheng-Nan He & Xiao-Wei Huang & Hai-Lan Luo & Hao-Yang Meng & Guo-Dong Lu & Yue-Ming Jiang & Tanara Vieira Peres & Yi-Ni Luo & Xiang-Fa Deng, 2017. "Sodium p -Aminosalicylic Acid Reverses Sub-Chronic Manganese-Induced Impairments of Spatial Learning and Memory Abilities in Rats, but Fails to Restore γ-Aminobutyric Acid Levels," IJERPH, MDPI, vol. 14(4), pages 1-15, April.
    5. Chao-Yan Ou & Yong-Hua He & Yi Sun & Lin Yang & Wen-Xiang Shi & Shao-Jun Li, 2019. "Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats," IJERPH, MDPI, vol. 16(12), pages 1-11, June.
    6. Cyrus S.H. Ho & Roger C.M. Ho & Amy M.L. Quek, 2018. "Chronic Manganese Toxicity Associated with Voltage-Gated Potassium Channel Complex Antibodies in a Relapsing Neuropsychiatric Disorder," IJERPH, MDPI, vol. 15(4), pages 1-8, April.

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