IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i4p4406-4421d48541.html
   My bibliography  Save this article

Early Exposure to Intermediate-Frequency Magnetic Fields Alters Brain Biomarkers without Histopathological Changes in Adult Mice

Author

Listed:
  • Tin-Tin Win-Shwe

    (Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan)

  • Shin Ohtani

    (Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako City, Saitama 351-0197, Japan)

  • Akira Ushiyama

    (Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako City, Saitama 351-0197, Japan)

  • Naoki Kunugita

    (Department of Environmental Health, National Institute of Public Health, 2-3-6 Minami, Wako City, Saitama 351-0197, Japan)

Abstract

Recently we have reported that intermediate-frequency magnetic field (IF-MF) exposure transiently altered the mRNA expression levels of memory function-related genes in the hippocampi of adult male mice. However, the effects of IF-MF exposure during brain development on neurological biomarkers have not yet been clarified. In the present study, we investigated the effect of IF-MF exposure during development on neurological and immunological markers in the mouse hippocampus in 3- and 7-week-old male mice. Pregnant C57BL/6J mice were exposed to IF-MF (21 kHz, 3.8 mT) for one hour per day from organogenesis period day 7 to 17. At adolescence, some IF-MF-exposed mice were further divided into exposure, recovery, and sham-exposure groups. The adolescent-exposure groups were exposed again to IF-MF from postnatal day 27 to 48. The expression of mRNA in the hippocampi was examined using a real-time RT-PCR method, and microglia activation was examined by immunohistochemical analysis. The expression levels of NR1 and NR2B as well as transcription factors (CaMKIV, CREB1), inflammatory mediators (COX2, IL-1 b,TNF-α), and the oxidative stress marker heme-oxygenase (HO)-1 were significantly increased in the IF-MF-exposed mice, compared with the control group, in the 7-week-old mice, but not in the 3-week-old mice. Microglia activation was not different between the control and other groups. This study provides the first evidence that early exposure to IF-MF reversibly affects the NMDA receptor, its related signaling pathways, and inflammatory mediators in the hippocampus of young adult mice; these changes are transient and recover after termination of exposure without histopathological changes.

Suggested Citation

  • Tin-Tin Win-Shwe & Shin Ohtani & Akira Ushiyama & Naoki Kunugita, 2015. "Early Exposure to Intermediate-Frequency Magnetic Fields Alters Brain Biomarkers without Histopathological Changes in Adult Mice," IJERPH, MDPI, vol. 12(4), pages 1-16, April.
  • Handle: RePEc:gam:jijerp:v:12:y:2015:i:4:p:4406-4421:d:48541
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/4/4406/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/12/4/4406/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Takumi Kitajima & Joachim Schüz & Akemi Morita & Wakaha Ikeda & Hirokazu Tanaka & Kayo Togawa & Esteban C. Gabazza & Masao Taki & Kuniaki Toriyabe & Tomoaki Ikeda & Shigeru Sokejima, 2022. "Measurement of Intermediate Frequency Magnetic Fields Generated by Household Induction Cookers for Epidemiological Studies and Development of an Exposure Estimation Model," IJERPH, MDPI, vol. 19(19), pages 1-13, September.
    2. Soe-Minn Htway & Mya-Thanda Sein & Keiko Nohara & Tin-Tin Win-Shwe, 2019. "Effects of Developmental Arsenic Exposure on the Social Behavior and Related Gene Expression in C3H Adult Male Mice," IJERPH, MDPI, vol. 16(2), pages 1-12, January.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:4:p:4406-4421:d:48541. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.