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Correlation of Zinc with Oxidative Stress Biomarkers

Author

Listed:
  • María Morales-Suárez-Varela

    (Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
    CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain
    These authors contributed equally to this work.)

  • Agustín Llopis-González

    (Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
    CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain
    These authors contributed equally to this work.)

  • Verónica González-Albert

    (Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain
    These authors contributed equally to this work.)

  • Raúl López-Izquierdo

    (Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain
    These authors contributed equally to this work.)

  • Isabel González-Manzano

    (Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain
    These authors contributed equally to this work.)

  • Javier Cháves

    (Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain
    CIBER de Diabetes y Enfermedades Metabólicas Asociados (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
    These authors contributed equally to this work.)

  • Vicente Huerta-Biosca

    (Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
    These authors contributed equally to this work.)

  • Juan C. Martin-Escudero

    (Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain
    These authors contributed equally to this work.)

Abstract

Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual’s physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20–59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson’s C = 0.639; p = 0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR = 2.80 (95%CI = 1.09–7.18) and AOR = 3.06 (95%CI = 0.96–9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension.

Suggested Citation

  • María Morales-Suárez-Varela & Agustín Llopis-González & Verónica González-Albert & Raúl López-Izquierdo & Isabel González-Manzano & Javier Cháves & Vicente Huerta-Biosca & Juan C. Martin-Escudero, 2015. "Correlation of Zinc with Oxidative Stress Biomarkers," IJERPH, MDPI, vol. 12(3), pages 1-17, March.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:3:p:3060-3076:d:46744
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