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Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities

Author

Listed:
  • Mattia Pedotti

    (Institute for Research in Biomedicine, Universita' della Svizzera italiana (USI) via Vela 6, 6500 Bellinzona, Switzerland)

  • Valentina Elisabetta Viviana Ferrero

    (European Commission—Directorate General—Joint Research Centre, Institute for Environment and Sustainability, Ispra, Varese 21027, Italy)

  • Teresa Lettieri

    (European Commission—Directorate General—Joint Research Centre, Institute for Environment and Sustainability, Ispra, Varese 21027, Italy)

  • Pascal Colpo

    (European Commission–Directorate General–Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Varese 21027, Italy)

  • Stephane Follonier

    (CSEM Landquart, Bahnhofstrasse 1, Landquart 7302, Switzerland)

  • Luigi Calzolai

    (European Commission–Directorate General–Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Varese 21027, Italy)

  • Luca Varani

    (Institute for Research in Biomedicine, Universita' della Svizzera italiana (USI) via Vela 6, 6500 Bellinzona, Switzerland)

Abstract

The estrogen receptor protein (ER) can bind a vast number of organic pollutants widely spread in the environment and collectively known as Endocrine Disrupting Chemicals, EDCs. Its broad selectivity makes it an ideal bio-recognition element for the detection of EDCs. Here we describe the strategy and rationale for the design of ER based biosensors and assays that generate a signal in the presence of EDCs. The opportunity to use either natural or rationally modified ER molecules is discussed. The latter approach was successfully applied in the EU-FP7 project RADAR, with the aim to develop a novel biosensor for the detection of organic pollutants both in the environment and in commercial water products.

Suggested Citation

  • Mattia Pedotti & Valentina Elisabetta Viviana Ferrero & Teresa Lettieri & Pascal Colpo & Stephane Follonier & Luigi Calzolai & Luca Varani, 2015. "Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities," IJERPH, MDPI, vol. 12(3), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:3:p:2612-2621:d:46195
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    Cited by:

    1. Stefania Marcheggiani & Roberto Spurio & Lucia Cimarelli & Duarte Tito & Laura Mancini, 2015. "Scientific Symposium “Small Solution for Big Water-Related Problems: Innovative Microarrays and Small Sensors to Cope with Water Quality and Food Security”," IJERPH, MDPI, vol. 12(12), pages 1-9, December.

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