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In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach

Author

Listed:
  • Han Lin

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Kaiming Yuan

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Linyan Li

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Shiwen Liu

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Senlin Li

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Guoxin Hu

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Qing-Quan Lian

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

  • Ren-Shan Ge

    (Department of Anesthesiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China)

Abstract

Diethylhexyl phthalate (DEHP) is one of the most widely utilized phthalate plasticizers. Previous studies have demonstrated that gestational or postnatal DEHP exposure induced adverse effects on rat brain development and function. In this study, we investigated the effects of gestational DEHP exposure on gene expression profiling in neonatal rat brain and cognitive function change at adulthood. Adult Sprague Dawley dams were orally treated with 10 or 750 mg/kg DEHP from gestational day 12 to 21. Some male pups were euthanized at postnatal day 1 for gene expression profiling, and the rest males were retained for water maze testing on postnatal day (PND) 56. DEHP showed dose-dependent impairment of learning and spatial memory from PND 56 to 63. Genome-wide microarray analysis showed that 10 and 750 mg/kg DEHP altered the gene expression in the neonatal rat brain. Ccnd1 and Cdc2 , two critical genes for neuron proliferation, were significantly down-regulated by DEHP. Interestingly, 750 mg/kg DEHP significantly increased Pmch level. Our study demonstrated the changed gene expression patterns after in utero DEHP exposure might partially contribute to the deficit of cognitive function at adulthood.

Suggested Citation

  • Han Lin & Kaiming Yuan & Linyan Li & Shiwen Liu & Senlin Li & Guoxin Hu & Qing-Quan Lian & Ren-Shan Ge, 2015. "In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach," IJERPH, MDPI, vol. 12(11), pages 1-15, October.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:11:p:13696-13710:d:57919
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    Cited by:

    1. Mariana Segovia-Mendoza & Margarita Isabel Palacios-Arreola & Lenin Pavón & Luis Enrique Becerril & Karen Elizabeth Nava-Castro & Omar Amador-Muñoz & Jorge Morales-Montor, 2022. "Environmental Pollution to Blame for Depressive Disorder?," IJERPH, MDPI, vol. 19(3), pages 1-13, February.
    2. Angela Giuliani & Mariachiara Zuccarini & Angelo Cichelli & Haroon Khan & Marcella Reale, 2020. "Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact," IJERPH, MDPI, vol. 17(16), pages 1-43, August.

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