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Toxicological Effects of Nickel Chloride on IgA + B Cells and sIgA, IgA, IgG, IgM in the Intestinal Mucosal Immunity in Broilers

Author

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  • Bangyuan Wu

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Hengmin Cui

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Xi Peng

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Jing Fang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Zhicai Zuo

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Junliang Deng

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Jianying Huang

    (Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

Abstract

The objective of this study was to investigate the toxicological effects of dietary NiCl 2 on IgA + B cells and the immunoglobulins including sIgA, IgA, IgG and IgM in the small intestine and cecal tonsil of broilers by the methods of immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). Two hundred and forty one-day-old avian broilers were randomly divided into four groups and fed on a control diet and three experimental diets supplemented with 300, 600, and 900 mg/kg NiCl 2 for 42 days. Compared with the control group, the IgA + B cell number and the sIgA, IgA, IgG, and IgM contents in the NiCl 2 -treated groups were significantly decreased ( p < 0.05 or p < 0.01). It was concluded that dietary NiCl 2 in the excess of 300 mg/kg had negative effects on the IgA + B cell number and the abovementioned immunoglobulin contents in the small intestine and the cecal tonsil. NiCl 2 -reduced sIgA, IgA, IgG and IgM contents is due to decrease in the population and/or the activation of B cell. The results suggest that NiCl 2 at high levels has intestinal mucosal humoral immunotoxicity in animals.

Suggested Citation

  • Bangyuan Wu & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Jianying Huang, 2014. "Toxicological Effects of Nickel Chloride on IgA + B Cells and sIgA, IgA, IgG, IgM in the Intestinal Mucosal Immunity in Broilers," IJERPH, MDPI, vol. 11(8), pages 1-18, August.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:8:p:8175-8192:d:39058
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    References listed on IDEAS

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    1. Juan Liu & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Hesong Wang & Bangyuan Wu & Yuanxin Deng & Kangping Wang, 2013. "Decreased IgA + B Cells Population and IgA, IgG, IgM Contents of the Cecal Tonsil Induced by Dietary High Fluorine in Broilers," IJERPH, MDPI, vol. 10(5), pages 1-11, May.
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