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Microstructural and Metabolic Recovery of Anhedonic Rat Brains: An In Vivo Diffusion MRI and 1 H-MRS Approach

Author

Listed:
  • Ahmad Raza Khan

    (Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Sune Nørhøj Jespersen

    (Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark
    Department of Physics and Astronomy, Aarhus University, 8000 Aarhus, Denmark)

  • Ove Wiborg

    (Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark)

  • Christopher Kroenke

    (Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR 97239, USA)

  • Brian Hansen

    (Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark)

Abstract

This article presents longitudinal 1 H-MR Spectroscopy ( 1 H-MRS) data from ventral hippocampus and in vivo diffusion MRI (dMRI) data of the brain from control and anhedonic rats. The 1 H-MRS and dMRI data were acquired using a 9.4 T preclinical imaging system. Before MRI experiments, animals were exposed to unpredictable chronic mild stress exposure for eight weeks and on the basis of a sucrose consumption test were identified as anhedonic and resilient. An age-matched group of animals, unexposed to the unpredictable chronic mild stress paradigm was considered as control. Data was acquired at the age of 18, 20 and 25 weeks in the anhedonic group and at the age of 18 and 22 weeks in the control group. This multimodal MRI data provides metabolic information of ventral hippocampus and dMRI based microstructural parameters of the brain.

Suggested Citation

  • Ahmad Raza Khan & Sune Nørhøj Jespersen & Ove Wiborg & Christopher Kroenke & Brian Hansen, 2018. "Microstructural and Metabolic Recovery of Anhedonic Rat Brains: An In Vivo Diffusion MRI and 1 H-MRS Approach," Data, MDPI, vol. 3(3), pages 1-4, July.
    • Handle: RePEc:gam:jdataj:v:3:y:2018:i:3:p:29-:d:160770
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