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A Comprehensive Lipidomic Dataset of Melittin-Induced Lipid Metabolism Alterations in Triple-Negative Breast Cancer Cells

Author

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  • Ronghua Zhang

    (Dongguan Maternal and Children Health Hospital, Dongguan 523000, China
    Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China
    These authors contributed equally to this work.)

  • He Zang

    (Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China
    Apitherapy Research Institute of Fujian Agriculture and Forestry University, Fuzhou 350002, China
    College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Wenhua Xu

    (Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China
    Apitherapy Research Institute of Fujian Agriculture and Forestry University, Fuzhou 350002, China
    College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Haiwen Zhuo

    (Dongguan Maternal and Children Health Hospital, Dongguan 523000, China
    Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China)

  • Qingwo Lu

    (Dongguan Maternal and Children Health Hospital, Dongguan 523000, China
    Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China)

  • Jianfeng Qiu

    (Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China
    Apitherapy Research Institute of Fujian Agriculture and Forestry University, Fuzhou 350002, China
    College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Dafu Chen

    (Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China
    Apitherapy Research Institute of Fujian Agriculture and Forestry University, Fuzhou 350002, China
    College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Rui Guo

    (Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China
    Apitherapy Research Institute of Fujian Agriculture and Forestry University, Fuzhou 350002, China
    College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Tizhen Yan

    (Dongguan Maternal and Children Health Hospital, Dongguan 523000, China
    Dongguan Technology Transfer Center of National & Local United Engineering Laboratory of Natural Biotoxin, Dongguan 523000, China
    National & Local United Engineering Laboratory of Natural Biotoxin, Fuzhou 350002, China)

Abstract

Melittin, the principal active peptide of bee venom, exhibits potent cytotoxicity against cancer cells. However, its lipid-level mechanisms remain unclear. Here, we present the first untargeted lipidomic dataset that reveals melittin-induced lipid remodeling in triple-negative breast cancer (TNBC) cells (MDA-MB-231). Cells were exposed to 4 μg/mL of melittin for 15 min, and lipid extracts were analyzed by employing high-resolution LC–MS/MS in both ion modes. Data were processed with XCMS and metaX for peak extraction, normalization, and metabolite annotation, followed by multivariate and KEGG pathway analyses. The results highlight significant alterations in phospholipids, sphingolipids, and acylglycerols, indicative of melittin-mediated disruption of membrane integrity and lipid metabolism. All raw and processed data are publicly accessible at NGDC (accession number PRJCA048975). This dataset not only serves as a comprehensive resource for investigating lipid-based mechanisms underlying melittin’s anticancer effects but also supports its potential in lipid-targeted therapeutic strategies for TNBC.

Suggested Citation

  • Ronghua Zhang & He Zang & Wenhua Xu & Haiwen Zhuo & Qingwo Lu & Jianfeng Qiu & Dafu Chen & Rui Guo & Tizhen Yan, 2026. "A Comprehensive Lipidomic Dataset of Melittin-Induced Lipid Metabolism Alterations in Triple-Negative Breast Cancer Cells," Data, MDPI, vol. 11(6), pages 1-8, June.
    • Handle: RePEc:gam:jdataj:v:11:y:2026:i:6:p:145-:d:1966574
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