Fe (III) Metal Complex Synthesis, Characterization and Biological Study Derived From (E)-4-Hydroxy-N'-(1-(4-Hydroxy-1-Methyl-2-Oxo-1, 2-Dihydroquinolin-3yl) Ethylidene) Benzohydrazide

The present study emphasizes heterocyclic hydrazone Schiff base ligand of 3-acetyl-4-hydroxy-1- methyl-2(1H)-quinolone (AHQ) and its Fe(III) metal complex. The metal complex synthesized using Schiff base hydrazone synthesized from 4-hydroxybenzhydrazide and 3-acetyl-4-hydroxy-1- methyl-2(1H)-quinolone. Hydrazone complex were subjected to elemental analysis, UV visible, magnetic susceptibility, FTIR,1H NMR spectra, mass spectra, thermal analysis, and antimicrobial activity. IR spectra indicate that free ligand exist in the hydrazo-ketone form in solid states. The ligand behaves as a neutral tridentate with coordination involving the carbonyl of 2(1H) quinolone, hydrazone nitrogen and keto oxygen of amide group that is ONO donor sites. The magnetic and spectral data indicate octahedral geometry for complex. The molar conductivity values indicating non electrolytic nature. The mass spectra and analytical data the stiochitometry of metal complex has been found to be the 2:1 ligand to metal ratio. Ea, ΔS, ΔH and ΔG parameters were evaluated for thermal decomposition stages of complex using Horowitz-Metzer and Coats-Redferm methods. The ligand and their metal chelets have been screened for their antibacterial activity using the Agar cup method at fixed concentration of 1% against microbial strains, E.coli, S. typhi, S. aureus, B. subtilis. The antibacterial screening of ligand and Fe(III) complex illustrates that ligand and Fe(III) complex seems to be inert towards the gram positive bacteria E. coli and S. typhi The complex show higher activity than ligand against gram negative bacteria S. aureus and B. subtilis. Antifungal activity of ligand and complex were tested in vitro against fungi that is A. niger, P. chrysogenum, f. moniliforme, A. flavus by poison plate method using potato dextrose agar medium at fixed (1%) concentration. Ligand does not show fungal activity but Fe(III) complex show better activity. It suggests that the incorporation of metal ion in the ligand results in increasing the antimicrobial activity.