Green Adeptness in the Synthesis of Silver Nanoparticles from Leaves of Colocasia Esculenta and Its Anticancer Activity

Cancer is a dangerous disease of uncontrollable cell fission in malignant tumor that invade the normal human body systems .In medical science the methods available to treat a cancer patient mainly includes surgery, chemotherapy and radiotherapy etc. As these known methods are very costly and have side effects with limitations of their use, there is need for effective and acceptable cancer therapeutics agents that would be non-toxic, highly efficacious against multiple cancers, palatable, cost effective. Medical plants have created great interest among researchers as they proved to possess anticancer activity (Gaidhani, 2013) and have no side effects. ). Colocasia esculenta (C. esculenta) is a tropical plant and widely distributed throughout Southern India and Southeast Asia. Colocasia esculenta Linn, (Family: Araceae) is an annual herbaceous plant with a long history of usage in traditional medicine in several countries across the world, especially in the tropical and subtropical regions.Nanoparticles of C. esculenta has not been used by any previous researcher for their anticancer activity, so far. This information gave us an impetus to synthesize the silver nanoparticles and evaluate its anticancer activity. Fresh leaves juice of Colocasia esculenta (5ml) mixed with 1 ml of Silver nitrate (AgNO3) solution having concentration 1M for reduction into Ag+ ions. Determination of cytotoxicity by MTT assay carried out on Prostate cancer cell line (PC3). IC50 value of Vincristine (standard) is 277.51 ± 30.05 µg/ml and IC50 value of juice of leaves is 28.57 ± 0.0 µg/ml.