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Complexation of Gadolinium Metal Ion with Medicinal Drugs in Mixed Solvent Media: Thermodynamic Aspect

Author

Listed:
  • Sandeep Sampal
  • Milind Gaikwad
  • Uddhav Chaudhar
  • Shailendrasingh Thakur

Abstract

We have used a pH metric titration technique in a 20% (v/v) ethanol-water mixture at three different temperatures at an ionic strength of 0.1M NaClO4 to measure the proton-ligand and metal-ligand stability constants of medicinal drugs containing Gadolinium metal ion (Gd3+). The logK values of the metal-ligand stability constant have been determined using the modified Irving-Rossotti and Calvin-Bjerrum method. The thermodynamic parameters Gibb's free energy change, entropy change and enthalpy change related to the complexation reactions were quantitatively determined.

Suggested Citation

  • Sandeep Sampal & Milind Gaikwad & Uddhav Chaudhar & Shailendrasingh Thakur, 2025. "Complexation of Gadolinium Metal Ion with Medicinal Drugs in Mixed Solvent Media: Thermodynamic Aspect," International Journal of Scientific Research in Science and Technology, Technoscience Academy, vol. 12(4), pages 1107-1113, August.
    • Handle: RePEc:etm:ijsrst:v12:y2025:i4:id:1117
    DOI: 10.32628/IJSRST251396
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