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Solvent-free Synthesis, Characterization and Biological Activity of Transition Metal Complexes of Schiff Base Ligand Derived (E)-N'-((1H-indol-3-yl) methylene)-4-chlorobenzohydrazide

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  • Sadashiv N. Sinkar

Abstract

The present study explores the microwave-assisted synthesis, characterization, and biologicalactivity of transition metal complexes of a Schiff base ligand derived from (E)-N'-((1H-indol-3-yl)methylene)-4-chlorobenzohydrazide. The ligand and its metal complexes were synthesized using an eco-friendly microwave irradiation method to enhance reaction efficiency and yield. Metal complexes were derived from nitrate of Co(II), Ni(II), Cu(II), Zn(II), salts with novel ligand at the end of the reaction all metal complexes show fine colour. By TLC and melting point of each complex was confirming the formation of metal complex. The synthesized compounds were characterized by various spectroscopic techniques, including FT-IR, UV-Vis, NMR, and elemental analysis. The metal complexes were further analyzed using Infrared spectroscopy, UV-visible spectroscopy and thermogravimetric analysis. The antibacterial activities of the Schiff base ligand and its metal complexes were tested against Escherichia coli, Staphylococcus aurous and Salmonella Typhi.

Suggested Citation

  • Sadashiv N. Sinkar, 2025. "Solvent-free Synthesis, Characterization and Biological Activity of Transition Metal Complexes of Schiff Base Ligand Derived (E)-N'-((1H-indol-3-yl) methylene)-4-chlorobenzohydrazide," International Journal of Scientific Research in Science and Technology, Technoscience Academy, vol. 12(4), pages 772-778, August.
    • Handle: RePEc:etm:ijsrst:v12:y2025:i4:id:1071
    DOI: 10.32628/IJSRST251353
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