Synthesis, Spectral Characterization and Antimicrobial Activity of Schiff Base Ligands Derived From 4-Substituted Benzaldehyde and Phenyl Urea

This study focuses on the synthesis, spectral characterization and antimicrobial activity of Schiff base ligands derived from 4-substituted benzaldehyde and phenyl urea by conventional method. Schiff bases, known for their broad coordination capabilities, were synthesized by reacting various 4-substituted benzaldehydes with phenyl urea under mild conditions. The structures of the synthesized ligands were confirmed by IR, NMR and GCMS spectroscopy. The IR spectra revealed characteristic absorption bands, NMR spectroscopy provides valuable information about the molecular structure, with distinct chemical shifts that reflect the presence of specific substituents and functional groups within the ligands. Additionally, GC-MS analysis was employed to assess the purity and molecular weight of the compounds, further confirming their identity. The disc diffusion technique was used to determine the antimicrobial activity of the synthesized ligands against the bacterial strains S. aureus, E. faecium, K. pneumoniae, P. aeruginosa and E. coli. Out of six ligands L1, L2 and L6 exhibit notable inhibitory activity, demonstrating strong antimicrobial efficacy with a zone of inhibition greater than 12 mm.