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Advanced Biologics and Smart Delivery Systems for Cardiovascular Diseases: A Comprehensive Review

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  • Paras Ghasura
  • Bhavika Murlidhar Sajnani
  • Mohammad Azhar Tanveer
  • Barath Raj R
  • Abhishek Sharma

Abstract

Background: Cardiovascular diseases (CVDs) remain the leading global cause of mortality, accounting for 20.5 million deaths annually. Traditional pharmacotherapies face limitations including poor bioavailability and systemic toxicity. Objective: To review the integration of advanced biological therapeutics with innovative drug delivery platforms for cardiovascular applications. Methods: Systematic analysis of 127 peer-reviewed articles from PubMed, Scopus, and Web of Science databases (2020-2025), focusing on FDA-approved biologics and emerging delivery technologies. Results: PCSK9 inhibitors demonstrate 50-60% LDL cholesterol reduction with significant cardiovascular event reduction. Advanced delivery systems including nanoparticles, stimuli-responsive carriers, and extracellular vesicles enhance therapeutic precision while minimizing adverse effects. Clinical successes include inclisiran achieving sustained efficacy with biannual dosing. Conclusion: The integration of biologics with smart delivery systems represents a paradigm shift toward personalized cardiovascular medicine with significant potential to improve patient outcomes.

Suggested Citation

  • Paras Ghasura & Bhavika Murlidhar Sajnani & Mohammad Azhar Tanveer & Barath Raj R & Abhishek Sharma, 2025. "Advanced Biologics and Smart Delivery Systems for Cardiovascular Diseases: A Comprehensive Review," International Journal of Scientific Research in Science and Technology, Technoscience Academy, vol. 12(4), pages 217-221, August.
    • Handle: RePEc:etm:ijsrst:v12:y2025:i4:id:1006
    DOI: 10.32628/IJSRST251268
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