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Determination of Vicrivirocin in Pharmaceutical Dosage Forms By Reverse Phase-High Performance Liquid Chromatographic (RP-HPLC) Method

Author

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  • Lavanya Patibandla
  • Narasimha Rao B.V

Abstract

The development and validation of a liquid chromatographic method ingradient mode for determination of vicrivirocin in pharmaceutical dosage forms by reverse phase-high performance liquid chromatographic (RP-HPLC) method. For assessing VICRIVIROC whole sale pharmaceuticals and pharmaceutical solutions, the study presents a sensitive, accurate, and accurate Opposite Phase HPLC method. The retention durations for was 8.13 minutes. The Elution solvent materials were liquid 0.1% percent (vol-by-vol) 0rtho-H3P03 (solvent-A, mobile phase) and CH3CN (solvent-B, mobile phase) in a gradient version of splitting up was used to elute the Vicriviroc at a flow rate of 1.0 mL-per-min was discovered to be the fairly ideal technique used to get a well-defined and tailing free chromatogram. The newly designed HPLC method required less time for reference criterion preparation and did not require any time-consuming removal. . An excellent linear partnership (r2=0.9996) was observed between the focus range of 60-360µg-per-mL. Vicriviroc's bulk assay was found to be 99.43% accurate. According to the recuperation research studies, on average, approximately 98.33% of Vicriviroc was recouped, indicating the approach's high accuracy. This indicates established technique is simple, linear, precise, delicate, and repeatable.

Suggested Citation

  • Lavanya Patibandla & Narasimha Rao B.V, 2024. "Determination of Vicrivirocin in Pharmaceutical Dosage Forms By Reverse Phase-High Performance Liquid Chromatographic (RP-HPLC) Method," International Journal of Scientific Research in Science and Technology, Technoscience Academy, vol. 11(2), pages 1093-1098, April.
    • Handle: RePEc:etm:ijsrst:v11:y2024:i2:id:841
    DOI: 10.32628/IJSRST251222731
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