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Acute Antidepressant Activity Investigation of Selected African Medicinal Plants in Mice: A Preliminary Study

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  • Ajibola Monisola Umarudeen
  • Mohammed Garba Magaji
  • Ferhat Khan
  • Abdulhakim Abubakar

Abstract

The therapeutic gap arising from high global incidence of depressive disorders and the efficacy and toxicity shortcomings of existing antidepressant drugs indicate a need to further search the plant kingdom with the goal of discovering novel antidepressant pharmacotherapeutic agents. Crude 50% ethanol Terminalia catappa (CETC), Tapinanthus dodoneifolius (CETD) and Bryophyllum pinnatum (CEBP) leaf extracts were investigated for their acute antidepressant activity on the forced swim (FST) and tail suspension (TST) tests. Groups of mice (n = 6) were each exposed to the tests 1 hour following oral administration of distilled water (10 ml/kg), extracts (125, 250 and 500 mg/kg body weight) and fluoxetine (20 mg/kg), using the mean immobility time as endpoint. Qualitative phytochemical analysis of these crude extracts indicated the presence of alkaloids, cardiac glycosides, saponins, phenolic compounds, tannins, steroids, carbohydrates, flavonoids, terpenoids and anthraquinones. Compared to distilled water treatments (FST, 84.16 ±3.92; TST, 82.85 ±5.84), CETC (FST, 84.17 ±4.44, 71.67 ±1.89, & 44.31 ±8.23*; TST, 79.03 ±2.62, 74.10 ±3.11, & 52.57 ±6.00*) and CEBP (FST, 77.02 ±2.70, 66.11 ±4.42 & 49.99 ±4.20*; TST, 69.51 ±7.24, 49.73 ±11.85* & 46.39 ±5.68**) treatments caused dose-dependent and significant (P

Suggested Citation

  • Ajibola Monisola Umarudeen & Mohammed Garba Magaji & Ferhat Khan & Abdulhakim Abubakar, 2023. "Acute Antidepressant Activity Investigation of Selected African Medicinal Plants in Mice: A Preliminary Study," European Journal of Pharmaceutical Research, European Open Science Publishing, vol. 3(5), pages 1-6, September.
    • Handle: RePEc:epw:pharma:v:3:y:2023:i:5:id:766
    DOI: 10.24018/ejpharma.2023.3.5.66
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