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Simple and Convenient Anti-myeloma Therapy for Elderly Patients with Significant Co-morbidities

Author

Listed:
  • Arumugam Manoharan

    (University of Wollongong, Australia)

  • Terry Golombick

    (Southern Sydney Haematology, Australia)

  • Terrence Harry Diamond

    (St George Hospital, University of New South Wales, Australia)

  • Sonia Ingrid Enggist

    (St. George Hospital, Australia)

  • Raj Ramakrishna

    (University of Wollongong, Australia)

Abstract

Treatment of multiple myeloma in elderly patients with significant comorbidities poses major clinical and logistic challenges; more so if the patients live in remote areas or in resource-poor countries. There is a need for simple and convenient, yet effective, therapeutic regimen which does not impact on the quality of life; and, is affordable for use in resource-poor countries. In this report we describe 11 patients (aged 63–90 years) with significant comorbidities, treated with a simple, all-oral therapeutic regimen comprising melphalan (4-6mg on alternate days x 7) prednisolone (50mg on alternate days x 7) and curcumin (Curcu ForteR, 1 twice daily from day 15-28) achieving effective disease control for 8 months to 9 years (median 2 years). The treatment was well tolerated, without any major adverse events or treatment-related symptom burden. We hope the convenience and cost-effectiveness of this regimen would be of interest, leading to further evaluation in larger clinical studies.

Suggested Citation

  • Arumugam Manoharan & Terry Golombick & Terrence Harry Diamond & Sonia Ingrid Enggist & Raj Ramakrishna, 2026. "Simple and Convenient Anti-myeloma Therapy for Elderly Patients with Significant Co-morbidities," European Journal of Medical and Health Sciences, European Open Science, vol. 8(1), pages 36-40, January.
    • Handle: RePEc:epw:ejmed0:v:8:y:2026:i:1:id:70068
    DOI: 10.24018/ejmed.2026.8.1.70068
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