IDEAS home Printed from https://ideas.repec.org/a/epw/ejmed0/v7y2025i5id42415.html

The Effect of Intraperitoneal Ozone Therapy onthe Number and Diameter of Placental Terminalis Villi in Wistar Rats Induced Preeclampsia Model with Deoxycorticosterone Acetate (DOCA)

Author

Listed:
  • I Gede Kadek Candra Mahardika

    (Udayana University / Ngoerah General Hospital, Indonesia)

  • I Nyoman Hariyasa Sanjaya

    (Ngoerah General Hospital, Indonesia)

  • Ryan Saktika Mulyana

    (Ngoerah General Hospital, Indonesia)

  • Putu Doster Mahayasa

    (Ngoerah General Hospital, Indonesia)

  • I Wayan Artana Putra

    (Ngoerah General Hospital, Indonesia)

  • I Gde Sastra Winata

    (Ngoerah General Hospital, Indonesia)

Abstract

Introduction: Preeclampsia is a pregnancy complication marked by hypertension and organ dysfunction, with impaired placental development, especially terminal villi, which are major contributing factors. Intraperitoneal ozone therapy improves blood circulation and tissue oxygenation. This study examined the effect of intraperitoneal ozone therapy on the number and diameter of placental terminal villi in Wistar rats in DOCA-induced preeclampsia model. Methods: This experimental laboratory study used a randomized posttest control only group design. Thirty-six pregnant femaleWistar rats were divided into two groups: control (no ozone therapy) and treatment (ozone injection of 1.2 mg with a 95%:5% oxygen/ozone gas mixture). On day 21 of pregnancy, the rats were sacrificed for placental collection. The number and diameter of terminal villi were examined histopathologically under a 40x microscope. Statistical analysis was performed using the Mann-Whitney test for number and T-test for diameter. Results: The treatment group had a significantly higher number and larger diameter of terminal villi than the control group (p

Suggested Citation

  • I Gede Kadek Candra Mahardika & I Nyoman Hariyasa Sanjaya & Ryan Saktika Mulyana & Putu Doster Mahayasa & I Wayan Artana Putra & I Gde Sastra Winata, 2025. "The Effect of Intraperitoneal Ozone Therapy onthe Number and Diameter of Placental Terminalis Villi in Wistar Rats Induced Preeclampsia Model with Deoxycorticosterone Acetate (DOCA)," European Journal of Medical and Health Sciences, European Open Science, vol. 7(5), pages 105-110, September.
    • Handle: RePEc:epw:ejmed0:v:7:y:2025:i:5:id:42415
    DOI: 10.24018/ejmed.2025.7.5.2415
    as

    Download full text from publisher

    File URL: https://eu-opensci.org/index.php/ejmed/article/view/42415
    File Function: Abstract page
    Download Restriction: no
    File URL: https://eu-opensci.org/index.php/ejmed/article/download/42415/10844
    File Function: Full text
    Download Restriction: no
    File URL: https://libkey.io/10.24018/ejmed.2025.7.5.2415?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:epw:ejmed0:v:7:y:2025:i:5:id:42415. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Support (email available below). General contact details of provider: https://eu-opensci.org/index.php/ejmed .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.