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Urothelial Plasmacytoid Carcinoma of Urethral Location with Prostatic Invasion: A Case Report

Author

Listed:
  • Khadija Khouz

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Rania Salhi

    (University Hospital Center Ibn Rochd, University Hassan II, Morocco)

  • Karima Ouadii

    (University Hospital Center Ibn Rochd, University Hassan II, Morocco)

  • Ghita Hatim

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Meryem Belhouari

    (University Hospital Center Ibn Rochd, University Hassan II, Morocco)

  • Tarik Chekrine

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Mouna Bourhafour

    (University Hospital Center Ibn Rochd, University Hassan II, Morocco)

  • Zineb Bouchbika

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Nadia Benchakroun

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Mehdi Karkouri

    (University Hospital Center Ibn Rochd, University Hassan II, Morocco)

  • Hassan Jouhadi

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Nezha Tawfik

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

  • Souha Sahraoui

    (University Hospital Centre Ibn Rochd, University Hassan II, Morocco)

Abstract

Plasmacytoid carcinoma is a rare and aggressive histological subtype of urothelial carcinoma, accounting for between 1% and 3% of urothelial carcinomas. The diagnostic confirmation relies on morphological and immunohistochemical analysis. We report the case of a 65-year-old male patient diagnosed with plasmacytoid urothelial carcinoma of the prostatic urethra (T4, N0, M0), with histological confirmation based on a biopsy obtained by transurethral resection. Immunohistochemical studies revealed positive epithelial markers and negative lymphoid markers. The patient underwent two cycles of systemic cisplatin-based chemotherapy. Surgery will be considered after further assessment. The therapeutic approach remains debated due to the heterogeneity of this histological subtype and its rarity. Radical cystectomy is the standard treatment for invasive muscle tumors without metastasis. Although cisplatin-based chemotherapy has been reported to be effective, local and metastatic recurrences are frequent. However, larger studies are needed to draw definitive conclusions and achieve consensus.

Suggested Citation

  • Khadija Khouz & Rania Salhi & Karima Ouadii & Ghita Hatim & Meryem Belhouari & Tarik Chekrine & Mouna Bourhafour & Zineb Bouchbika & Nadia Benchakroun & Mehdi Karkouri & Hassan Jouhadi & Nezha Tawfik , 2025. "Urothelial Plasmacytoid Carcinoma of Urethral Location with Prostatic Invasion: A Case Report," European Journal of Medical and Health Sciences, European Open Science, vol. 7(5), pages 51-53, September.
    • Handle: RePEc:epw:ejmed0:v:7:y:2025:i:5:id:42319
    DOI: 10.24018/ejmed.2025.7.5.2319
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