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Effectiveness of Stem Cell Therapy for Bone Fracture Healing in Patients with Comorbidities: A Systematic Review and Meta-Analysis

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  • Revina Amalia Saputra

    (General Practitioner, Siloam Purwakarta, Indonesia)

  • Widya Arsa

    (Department of Orthopaedic and Traumatology, Siloam Purwakarta, Indonesia)

  • Yudha Mathan Sakti

    (Department of Orthopaedics and Traumatology, Dr. Sardjito General Hospital/Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Sleman Regency, Yogyakarta Special Region, Indonesia)

Abstract

Over the past few decades, significant advancements have been made to enhance fracture management. However, complications such as nonunion and delayed union remain prevalent, particularly in patients with comorbidities. Cell therapy, particularly the use of mesenchymal stem cells (MSCs) and osteoblast injections, has emerged as a promising approach for accelerating fracture healing. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We reviewed the relevant scientific literature published between 2010 and 2023. The pooled risk ratio (RR) with a 95% confidence interval (CI) was assessed using a fixed or random-effects model. A p-value of

Suggested Citation

  • Revina Amalia Saputra & Widya Arsa & Yudha Mathan Sakti, 2025. "Effectiveness of Stem Cell Therapy for Bone Fracture Healing in Patients with Comorbidities: A Systematic Review and Meta-Analysis," European Journal of Medical and Health Sciences, European Open Science, vol. 7(2), pages 67-72, March.
    • Handle: RePEc:epw:ejmed0:v:7:y:2025:i:2:id:42278
    DOI: 10.24018/ejmed.2025.7.2.2278
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