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Detection of Anti-HBc (Total) and HBV-DNA in Hepatitis B Virus Surface Antigen Negative Blood Donors

Author

Listed:
  • Ataul Karim

    (Deputy Program Manager, M-Phil (Microbiology), Hospital Services Management, DGHS, Bangladesh)

  • Md. Shamiul Islam Sady

    (Professor Director, National Institute of Preventive and Social Medicine, Bangladesh)

  • Surajit Dutta

    (Assistant Professor, Department of Surgery, Dhaka Medical College Hospital, Bangladesh)

  • Rojy Siddiqee

    (Medical Officer, Upozilla Health Complex, Bangladesh)

  • Sakit Mahmud

    (Junior Consultant, (Medicine), OSD- DGHS; DPM-01- Hospital, Services Management (HSM), Directorate General of Health Services (DGHS), Bangladesh)

  • Aminul Haque

    (DPM, HSM, MD (Cardiology), Directorate General of Health Services, Bangladesh)

  • Arup Kanti Dewanjee

    (Professor Head, Department of Microbiology, Marine City Medical College, Bangladesh)

  • Nasima Aktar

    (Professor Former Head, Department of Microbiology, Chittagong Medical College, Bangladesh)

Abstract

Hepatitis B virus (HBV) infection remains a critical global public health concern. The introduction of hepatitis B surface antigen (HBsAg) testing in routine blood donor screening during the early 1970s significantly improved transfusion safety. Despite this progress, cases of HBV transmission from blood components testing negative for HBsAg have been documented. Research indicates that some donors, while negative for HBsAg but positive for anti-HBc, can still replicate the hepatitis B virus. These donors may carry and sustain HBV-DNA in their liver and bloodstream, representing a latent source of HBV transmission. This cross-sectional study involved 300 HBsAg negative individuals who visited the Transfusion Medicine Department at Chittagong Medical College Hospital and the Shandhani Chittagong Medical College unit for blood donation between July 2016 and June 2017. Of these participants, 58.66% were voluntary donors, while 41.33% were replacement donors. The study revealed that the majority of participants were aged 21–30 years, with a mean age of 27.09 years. Males accounted for 83% of the donors, whereas females comprised 17%. The findings showed that 49 donors (16.3%) tested positive for anti-HBc (total) among the 300 HBsAg-negative donors. Anti-HBc (total) positivity was more prevalent among replacement donors (9.31%) compared to voluntary donors (7%), with the difference being statistically significant (P

Suggested Citation

  • Ataul Karim & Md. Shamiul Islam Sady & Surajit Dutta & Rojy Siddiqee & Sakit Mahmud & Aminul Haque & Arup Kanti Dewanjee & Nasima Aktar, 2025. "Detection of Anti-HBc (Total) and HBV-DNA in Hepatitis B Virus Surface Antigen Negative Blood Donors," European Journal of Medical and Health Sciences, European Open Science, vol. 7(2), pages 35-40, March.
    • Handle: RePEc:epw:ejmed0:v:7:y:2025:i:2:id:42222
    DOI: 10.24018/ejmed.2025.7.2.2222
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