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Differences in Plasma Endothelin-1 Levels Before and After MgSO4 Administration in Pregnant Women with Preeclampsia

Author

Listed:
  • I Wayan Artana Putra

    (Fetomaternal Division, Department of Obstetrics and Gynecology, Prof. Dr. I. G. N. G. Ngoerah General Hospital, Indonesia)

  • Evert Solomon Pangkahila

    (Fetomaternal Division, Department of Obstetrics and Gynecology, Prof. Dr. I. G. N. G. Ngoerah General Hospital, Indonesia)

  • I Nyoman Bayu Mahendra

    (Onco-Gynecology Division, Department of Obstetrics and Gynecology, Prof. Dr. I. G. N. G. Ngoerah General Hospital, Indonesia)

  • Kadek Fajar Marta

    (Urogynecology Reconstruction Division, Department of Obstetrics and Gynecology, Prof. Dr. I. G. N. G. Ngoerah General Hospital, Indonesia)

  • I Made Darmayasa

    (Obstetric and Gynecology Social Division, Department of Obstetrics and Gynecology, Prof. Dr. I. G. N. G. Ngoerah General Hospital, Indonesia)

  • Putu Ngurah Aeland Prilaksana Kalimantara

    (Department of Obstetrics and Gynecology, Udayana University, Prof. Dr. I. G. N. G. Ngoerah General Hospital, Indonesia)

Abstract

Introduction: Preeclampsia (PE) is a major cause of maternal morbidity and mortality, particularly in low-resource settings. Although Magnesium Sulfate (MgSO4) is the standard treatment for preventing eclampsia, its precise effects on vascular function, especially regarding Endothelin-1 (ET-1) levels, remain unclear. ET-1, a potent vasoconstrictor, is elevated in hypertensive disorders of pregnancy, contributing to endothelial dysfunction in PE. This study aims to investigate the impact of MgSO4 therapy on plasma ET-1 levels in pregnant women diagnosed with severe PE. Method: This observational follow-up study was conducted at RSUP Prof. Dr. I. G. N. G. Ngoerah, Denpasar, starting in October 2022. Participants included pregnant women with severe PE, aged 20–40 weeks of gestation, receiving MgSO4 therapy. Patients with chronic conditions such as diabetes or pre-existing hypertension were excluded. Blood samples were collected before and after MgSO4 administration, and plasma ET-1 levels were measured using enzyme-linked immunosorbent assay (ELISA). Statistical analysis was conducted using the Wilcoxon test, with a significance level set at p

Suggested Citation

  • I Wayan Artana Putra & Evert Solomon Pangkahila & I Nyoman Bayu Mahendra & Kadek Fajar Marta & I Made Darmayasa & Putu Ngurah Aeland Prilaksana Kalimantara, 2025. "Differences in Plasma Endothelin-1 Levels Before and After MgSO4 Administration in Pregnant Women with Preeclampsia," European Journal of Medical and Health Sciences, European Open Science, vol. 7(1), pages 33-38, January.
    • Handle: RePEc:epw:ejmed0:v:7:y:2025:i:1:id:42228
    DOI: 10.24018/ejmed.2025.7.1.2228
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