IDEAS home Printed from https://ideas.repec.org/a/epw/ejmed0/v6y2024i1id42008.html

Elevated Salivary IL-8 Levels in Patients with Aphthous Ulceration and Rheumatoid Arthritis: A Cross-Sectional Study

Author

Listed:
  • Karar Abdulzahra Mahdi

    (University of Kufa, Iraq)

  • Dunya Malhan Hanweet

    (University of Kufa, Iraq)

  • Muhassad H. Al-Mudhafar

    (niversity of Kufa, Iraq)

Abstract

Background: Aphthous ulcers (AU) and Rheumatoid Arthritis (RA) are conditions marked by inflammation, with Interleukin 8 (IL-8) playing a significant role in their pathogenesis. This study aims to evaluate the levels of IL-8 in saliva among individuals with AU, RA, both conditions and healthy controls, providing insights into its potential as a diagnostic biomarker and therapeutic target. Methods: The study, endorsed by the Ethics Committee of the University of Kufa, College of Dentistry, Department of Oral Pathology, employed a descriptive, analytical, and cross-sectional approach. Participants included patients with AU, RA, both conditions and a control group, totalling 94 individuals. Exclusion criteria encompassed medication use, other systemic conditions, and lifestyle factors like smoking. Saliva and blood samples were collected for IL-8 concentration measurement using ELISA and for Rheumatoid Factor (RF) and anti-CCP analysis. Results: Analysis showed the highest average salivary IL-8 levels in patients with both AU and RA (483.33 ± 141.20 pg/mL), followed by the RA group (338.57 ± 79.11 pg/mL), the AU group (381 ± 108.48 pg/mL), and the control group (213.69 ± 84.65 pg/mL). Significant differences in IL-8 levels were observed between these groups, with the combined AU and RA groups showing the highest concentrations. However, the variation in IL-8 levels between those who have both AU and RA and those with only RA was not statistically significant. Conclusion: The study highlights a distinct elevation in salivary IL-8 levels in patients with AU and RA, particularly in those suffering from both conditions.

Suggested Citation

  • Karar Abdulzahra Mahdi & Dunya Malhan Hanweet & Muhassad H. Al-Mudhafar, 2024. "Elevated Salivary IL-8 Levels in Patients with Aphthous Ulceration and Rheumatoid Arthritis: A Cross-Sectional Study," European Journal of Medical and Health Sciences, European Open Science, vol. 6(1), pages 25-29, January.
  • Handle: RePEc:epw:ejmed0:v:6:y:2024:i:1:id:42008
    DOI: 10.24018/ejmed.2024.6.1.2008
    as

    Download full text from publisher

    File URL: https://eu-opensci.org/index.php/ejmed/article/view/42008
    File Function: Abstract page
    Download Restriction: no

    File URL: https://eu-opensci.org/index.php/ejmed/article/download/42008/10049
    File Function: Full text
    Download Restriction: no

    File URL: https://libkey.io/10.24018/ejmed.2024.6.1.2008?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:epw:ejmed0:v:6:y:2024:i:1:id:42008. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Support (email available below). General contact details of provider: https://eu-opensci.org/index.php/ejmed .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.