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Low Expression of p53 in Sacrouterine Ligament as A Risk Factor for Stage III-IV Uterine Prolapse

Author

Listed:
  • Dewa Gede Sidan Pradnyandita

    (Sanglah General Hospital, Indonesia)

  • I Wayan Megadhana

    (Udayana University, Indonesia)

  • Ketut Suwiyoga

    (Udayana University, Indonesia)

  • I Made Darmayasa

    (Udayana University, Indonesia)

  • Anom Suardika

    (Udayana University, Indonesia)

  • Endang Sri Widiyanti

    (Udayana University, Indonesia)

Abstract

Introduction: As life expectancy increases, so does the incidence of pelvic organ prolapse (POP). Low expression of p53 may lead to reduced production and deposition of elastin in the extracellular matrix thus it may increase the risk for POP. This study aims to determine the relationship between p53 expression and the incidence of grade III-IV POP. Methods: This observational case-control study involved women with grade III-IV POP that underwent a total hysterectomy at Sanglah General Hospital Denpasar as the case group. The control group was non-prolapsed women who were matched to the case for the variables of age, parity, body mass index (BMI), and occupation to minimize bias. The p53 expression was grouped into low (

Suggested Citation

  • Dewa Gede Sidan Pradnyandita & I Wayan Megadhana & Ketut Suwiyoga & I Made Darmayasa & Anom Suardika & Endang Sri Widiyanti, 2022. "Low Expression of p53 in Sacrouterine Ligament as A Risk Factor for Stage III-IV Uterine Prolapse," European Journal of Medical and Health Sciences, European Open Science, vol. 4(5), pages 100-104, September.
    • Handle: RePEc:epw:ejmed0:v:4:y:2022:i:5:id:41461
    DOI: 10.24018/ejmed.2022.4.5.1461
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