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Haematological and Biochemical Safety Evaluation of the Aqueous Fraction of the Methanol Extract of the Leaf of Musa paradisiaca Linn

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  • Ememobong Gideon Asuquo

    (University of Uyo, Nigeria)

  • Chinweizu Ejikeme Udobi

    (University of Uyo, Nigeria)

Abstract

The knowledge of the safety of a medicinal plant is important before it can be administered as a pharmacological agent in either animal or man. Thus, the effect of the aqueous fraction of the methanol extract of the leaf of Musa paradisiacal L. on the haematological and biochemical indices of experimental Swiss albino mice was studied. The dose of the extract that killed 50% of the animal population (LD50) was determined using the Miller and Tinter method while the effect of the extract on the biochemical and haematological indices of wistar rats was determined after 21 days of administration of three different doses of the extract namely low, medium and high doses which are 10, 20 and 30% of the obtained LD50. Results obtained showed an LD50 of 5754.40±694.25 mg/kg of body weight indicating that the leaf of Musa paradisiaca is nontoxic. Results further showed that the extract had no significant (p

Suggested Citation

  • Ememobong Gideon Asuquo & Chinweizu Ejikeme Udobi, 2022. "Haematological and Biochemical Safety Evaluation of the Aqueous Fraction of the Methanol Extract of the Leaf of Musa paradisiaca Linn," European Journal of Medical and Health Sciences, European Open Science, vol. 4(3), pages 46-51, May.
    • Handle: RePEc:epw:ejmed0:v:4:y:2022:i:3:id:41322
    DOI: 10.24018/ejmed.2022.4.3.1322
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