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Progression of Disease with Neo-Adjuvant Chemotherapy in Locally Advanced Cervical Cancer: Case Reports and Literature Review

Author

Listed:
  • Azma Baharudin

    (Hospital Serdang, Malaysia)

  • Zainab Yahaya

    (Hospital Serdang, Malaysia)

  • Habibah Abdul Hamid

    (Universiti Putra Malaysia (UPM), Malaysia)

Abstract

Background: Optimal treatment for locally advanced cervical cancer is still a controversial issue as the current standard therapy is associated with radiation toxicity. Neo-adjuvant chemotherapy followed by surgery is an alternative treatment modality which has promising outcomes. Cases: Two cases of cervical carcinoma, aged 33 and 40 years old, stage 1b2 and 1b3, given neoadjuvant chemotherapy (NACT) with combination of platinum-based agents and Taxane, and planned for radical surgery after completion of chemotherapy. Result: Progression of disease observed in both cases after 3rd cycle of chemotherapy required change of treatment modalities to standard chemoradiation therapy (CCRT). Conclusion: NACT followed by surgery has promising outcomes as it gives advantages in lower long-term complication, targeted in younger-aged group and sexually active women for better quality of life, besides offering similar survival rates compared with CCRT. Estimation of response rate to chemotherapy plays a major role in patient selection in order to have successful outcomes.

Suggested Citation

  • Azma Baharudin & Zainab Yahaya & Habibah Abdul Hamid, 2022. "Progression of Disease with Neo-Adjuvant Chemotherapy in Locally Advanced Cervical Cancer: Case Reports and Literature Review," European Journal of Medical and Health Sciences, European Open Science, vol. 4(3), pages 20-23, May.
    • Handle: RePEc:epw:ejmed0:v:4:y:2022:i:3:id:41176
    DOI: 10.24018/ejmed.2022.4.3.1176
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