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Effect of Vitamin D on Elastin and Collagen Expression: In Vitro Study of Pelvic Organ Prolapse Prevention

Author

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  • . Rahajeng

    (Brawijaya University, Indonesia)

  • Tatit Nurseta

    (Brawijaya University, Indonesia)

  • Bambang Rahardjo

    (Brawijaya University, Indonesia)

  • Yahya Irwanto

    (Brawijaya University, Indonesia)

  • Daniel Alexander Suseno

    (Brawijaya University, Indonesia)

Abstract

Introduction: Pelvic organ prolapse is defined as abnormal protrusion of the pelvic organ beyond its normal anatomical site. It occurs due to the structural weakness of the connective tissue that plays a role in supporting the uterus on the pelvic floor, specifically elastin and collagen. Our study evaluated the effect of vitamin D [1,25(OH)2D3] in preventing pelvic organ prolapse by aggregating elastin and collagen expression. Material and Methods: A true experimental research was carried out by assessing the cell cultures of sacro-uterine ligament from female patients who underwent hysterectomy. The cell cultures were divided into groups that were exposed to vitamin D at different concentrations of 100 µM, 200 µM, 400 µM, 800 µM, and control without any exposure. The expression of elastin and collagen was subsequently analyzed using immunofluorescence and ELISA method. Results: This study showed that exposure to vitamin D significantly affected elastin expression (p-value

Suggested Citation

  • . Rahajeng & Tatit Nurseta & Bambang Rahardjo & Yahya Irwanto & Daniel Alexander Suseno, 2021. "Effect of Vitamin D on Elastin and Collagen Expression: In Vitro Study of Pelvic Organ Prolapse Prevention," European Journal of Medical and Health Sciences, European Open Science, vol. 3(1), pages 37-41, January.
    • Handle: RePEc:epw:ejmed0:v:3:y:2021:i:1:id:40657
    DOI: 10.24018/ejmed.2021.3.1.657
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