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Multiple Causes of Dementia as Engineered Senescence

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  • Mario Dominic Garrett

Abstract

All traumas—cranial, cardiovascular, hormone, viral, bacterial, fungi, parasites, misfolded protein, genetic, behavior, environmental and medication—affect the brain. This paper itemizes studies showing the many different causes of dementia including Alzheimer’s disease. Causes interact with each other, act sequentially by preparing the optimal conditions for its successor, initiate other diseases, allow for other traumas to accumulate and degrade protective features of the brain. Since such age-related cognitive impairment is not exclusively a human attribute there might be support for an evolutionary theory of dementia. Relying on theories of antagonistic pleiotropy and polymorphism, the brain has been designed to sequester trauma. Because of increased longevity, the short-term tactic of sequestering trauma becomes a long-term liability. We are engineered to sequester these insults until a tipping point is reached. Dementia is an evolutionary trade-off for longevity. We cannot cure dementia without understanding the overall biology of aging.

Suggested Citation

  • Mario Dominic Garrett, 2020. "Multiple Causes of Dementia as Engineered Senescence," European Journal of Medical and Health Sciences, European Open Science, vol. 2(2), March.
    • Handle: RePEc:epw:ejmed0:v:2:y:2020:i:2:id:40227
    DOI: 10.24018/ejmed.2020.2.2.227
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    1. Emmanuelle Le Chatelier & Trine Nielsen & Junjie Qin & Edi Prifti & Falk Hildebrand & Gwen Falony & Mathieu Almeida & Manimozhiyan Arumugam & Jean-Michel Batto & Sean Kennedy & Pierre Leonard & Junhua, 2013. "Richness of human gut microbiome correlates with metabolic markers," Nature, Nature, vol. 500(7464), pages 541-546, August.
    2. Yanjun Li & Yongming Li & Xiaotao Li & Shuang Zhang & Jincheng Zhao & Xiaofeng Zhu & Guozhong Tian, 2017. "Head Injury as a Risk Factor for Dementia and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of 32 Observational Studies," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
    3. Min-Sik Kim & Sneha M. Pinto & Derese Getnet & Raja Sekhar Nirujogi & Srikanth S. Manda & Raghothama Chaerkady & Anil K. Madugundu & Dhanashree S. Kelkar & Ruth Isserlin & Shobhit Jain & Joji K. Thoma, 2014. "A draft map of the human proteome," Nature, Nature, vol. 509(7502), pages 575-581, May.
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    Cited by:

    1. Mario Dominic Garrett, 2021. "Psychopathology of Dementia: Psychology’s Pivotal Role," European Journal of Medical and Health Sciences, European Open Science, vol. 3(5), pages 61-69, September.

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