Factors Coupled the Choice of Clopidogrel, Prasugrel And Ticagrelor in Patients Undergoing Percutaneous Coronary Intervention

Background:Percutaneous coronary intervention is used in patients whose coronary arteries are narrowed and blood flow to the heart are obstructed. Antiplatelets has a major role in patients who have undergone PCI. Selection of antiplatelets is very important and study reveals about the factors associated with the selection of antiplatelet agents, thereby providing maximum therapeutic outcome. Objective: To determine the factors influencing the selection of antiplatelet agents in patients undergoing PCI. Materials And Methods: A prospective observational study was conducted on antiplatelet agents by carefully analyzing the case records of patients who were selected as the study population. For collection of data, a data collection form was prepared. At the end of the study regression analysis was done to find out the factors influencing selection of antiplatelet agents. Results: 350 patients were followed, 71.4% males and 28.6 females. Of the 250 male patients 67- SVD, 99- DVD and 84- TVD; whereas in females 29-SVD, 36- DVD and 35- TVD. There was a statistically significant correlation between hypertension (p=0.029), body weight (p=0.001), number of stent implanted (p=0.009) and diameter of stent (p=0.022) with drug. The prevalence of CAD was more in the age group 51-75 years and clopidogrel was the most preferred. Prasugrel was not used in patients greater than 75 years because of major bleeding. None of the patients with renal dysfunction were treated with ticagrelor. Conclusion: Hypertension, bodyweight, number of stent implanted, and diameter of stent were significantly associated with the selection of antiplatelet agents in patients undergoing PTCA.