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Aminotransferase Activity Measurement on The Atellica® CH 930 and The Architect® ci4100

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  • Soumia Nachate
  • Hind Zrikem
  • Fayrouz Debbagh
  • Saliha Chellak
  • Abderrahman Boukhira

Abstract

The Atellica® CH 930 is a new biochemistry analyzer recently introduced to the world market. This study aims to compare the Atellica® CH 930 analyzer to the Architect® ci4100 analyzer for measurement of serum aspartate (AST) and alanine (ALT) aminotransferase concentrations. A total of 112 sera were tested on the Architect® ci4100 and the Atellica® CH 930 analyzers for ALT and AST activities, and the results were compared using the paired Student's t-test, Pearson’s correlation analysis, Passing-Bablok regression analysis, and Bland–Altman plots. There was no significant difference between the means of the ALT and AST concentrations measured using the two instruments (p = 0.659 and p = 0.506, respectively). For ALT, the Passing-Bablok equation was Atellica=1.11 ×Architect -0.96, with a correlation coefficient (r) of 0.999. For AST, it was Atellica=1.08 ×Architect -0.50, with r = 0.998. According to Bland-Altman plots, the mean difference between both methods was 2.3 IU/L (4.3%) for ALT and 2.1 IU/L (5.8%) for AST, with 95.53% and 96.43% of points within the interval [0 ± 1.96 × SD], respectively. These findings demonstrated that the Atellica® CH 930 and Architect® ci4100 methods had an overall good agreement in aminotransferase measurement.

Suggested Citation

  • Soumia Nachate & Hind Zrikem & Fayrouz Debbagh & Saliha Chellak & Abderrahman Boukhira, 2023. "Aminotransferase Activity Measurement on The Atellica® CH 930 and The Architect® ci4100," European Journal of Biology and Biotechnology, European Open Science, vol. 4(3), pages 41-45, April.
    • Handle: RePEc:epw:ejbio0:v:4:y:2023:i:3:id:17472
    DOI: 10.24018/ejbio.2023.4.4.472
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    1. Rafdzah Zaki & Awang Bulgiba & Roshidi Ismail & Noor Azina Ismail, 2012. "Statistical Methods Used to Test for Agreement of Medical Instruments Measuring Continuous Variables in Method Comparison Studies: A Systematic Review," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-7, May.
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