Aminotransferase Activity Measurement on The Atellica® CH 930 and The Architect® ci4100

The Atellica® CH 930 is a new biochemistry analyzer recently introduced to the world market. This study aims to compare the Atellica® CH 930 analyzer to the Architect® ci4100 analyzer for measurement of serum aspartate (AST) and alanine (ALT) aminotransferase concentrations. A total of 112 sera were tested on the Architect® ci4100 and the Atellica® CH 930 analyzers for ALT and AST activities, and the results were compared using the paired Student's t-test, Pearson’s correlation analysis, Passing-Bablok regression analysis, and Bland–Altman plots. There was no significant difference between the means of the ALT and AST concentrations measured using the two instruments (p = 0.659 and p = 0.506, respectively). For ALT, the Passing-Bablok equation was Atellica=1.11 ×Architect -0.96, with a correlation coefficient (r) of 0.999. For AST, it was Atellica=1.08 ×Architect -0.50, with r = 0.998. According to Bland-Altman plots, the mean difference between both methods was 2.3 IU/L (4.3%) for ALT and 2.1 IU/L (5.8%) for AST, with 95.53% and 96.43% of points within the interval [0 ± 1.96 × SD], respectively. These findings demonstrated that the Atellica® CH 930 and Architect® ci4100 methods had an overall good agreement in aminotransferase measurement.