IDEAS home Printed from https://ideas.repec.org/a/epw/ejbio0/v3y2022i1id17321.html

New Pathophysiology Insight of Gut Microbiota’s Influence on Systemic Lupus Erythematosus: A Brief Review

Author

Listed:
  • Dewi Purwita Agustini

Abstract

Systemic lupus erythematosus (SLE) is a commonly found chronic autoimmune disease that affects multiple organs and systems. According to a new study, commensal gut microbiota promotes chronic autoimmunity in SLE patients with a lower Firmicutes/Bacteroidetes ratio. It has to do with the activation of inflammatory mediators such as toll-like receptors (TLRs), NOD-like receptors, adaptive immune response, and antimicrobial peptides mucins, defensins, and immunoglobulin A production. Aside from that, a decreased Firmicutes/Bacteroidetes ratio may cause T helper cells and regulatory T cells to become activated, both of which are linked to autoimmune activation in SLE. Theoretically, the immunomodulatory influence of food components in immune system activation has been the focus of nutrition for SLE patients, but probiotics and prebiotics have also been shown to dramatically enhance gut microbiota associated to SLE.

Suggested Citation

  • Dewi Purwita Agustini, 2022. "New Pathophysiology Insight of Gut Microbiota’s Influence on Systemic Lupus Erythematosus: A Brief Review," European Journal of Biology and Biotechnology, European Open Science, vol. 3(1), pages 1-4, January.
    • Handle: RePEc:epw:ejbio0:v:3:y:2022:i:1:id:17321
    DOI: 10.24018/ejbio.2022.3.1.321
    as

    Download full text from publisher

    File URL: https://eu-opensci.org/index.php/ejbio/article/view/17321
    File Function: Abstract page
    Download Restriction: no
    File URL: https://eu-opensci.org/index.php/ejbio/article/download/17321/4228
    File Function: Full text
    Download Restriction: no
    File URL: https://libkey.io/10.24018/ejbio.2022.3.1.321?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tanya Yatsunenko & Federico E. Rey & Mark J. Manary & Indi Trehan & Maria Gloria Dominguez-Bello & Monica Contreras & Magda Magris & Glida Hidalgo & Robert N. Baldassano & Andrey P. Anokhin & Andrew C, 2012. "Human gut microbiome viewed across age and geography," Nature, Nature, vol. 486(7402), pages 222-227, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Muntsa Rocafort & David B. Gootenberg & Jesús M. Luévano & Jeffrey M. Paer & Matthew R. Hayward & Juliet T. Bramante & Musie S. Ghebremichael & Jiawu Xu & Zoe H. Rogers & Alexander R. Munoz & Samson O, 2024. "HIV-associated gut microbial alterations are dependent on host and geographic context," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Ruairi C. Robertson & Thaddeus J. Edens & Lynnea Carr & Kuda Mutasa & Ethan K. Gough & Ceri Evans & Hyun Min Geum & Iman Baharmand & Sandeep K. Gill & Robert Ntozini & Laura E. Smith & Bernard Chasekw, 2023. "The gut microbiome and early-life growth in a population with high prevalence of stunting," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Kristin M. Ham & Layne K. Bower & Shanping Li & Hernan Lorenzi & Safiatou Doumbo & Didier Doumtabe & Kassoum Kayentao & Aissata Ongoiba & Boubacar Traore & Peter D. Crompton & Nathan W. Schmidt, 2024. "The gut microbiome is associated with susceptibility to febrile malaria in Malian children," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. John Molloy & Katrina Allen & Fiona Collier & Mimi L. K. Tang & Alister C. Ward & Peter Vuillermin, 2013. "The Potential Link between Gut Microbiota and IgE-Mediated Food Allergy in Early Life," IJERPH, MDPI, vol. 10(12), pages 1-22, December.
    5. Antonella Gagliardi & Valentina Totino & Fatima Cacciotti & Valerio Iebba & Bruna Neroni & Giulia Bonfiglio & Maria Trancassini & Claudio Passariello & Fabrizio Pantanella & Serena Schippa, 2018. "Rebuilding the Gut Microbiota Ecosystem," IJERPH, MDPI, vol. 15(8), pages 1-24, August.
    6. Allison G. White & George S. Watts & Zhenqiang Lu & Maria M. Meza-Montenegro & Eric A. Lutz & Philip Harber & Jefferey L. Burgess, 2014. "Environmental Arsenic Exposure and Microbiota in Induced Sputum," IJERPH, MDPI, vol. 11(2), pages 1-15, February.
    7. Sanzhima Garmaeva & Trishla Sinha & Anastasia Gulyaeva & Nataliia Kuzub & Johanne E. Spreckels & Sergio Andreu-Sánchez & Ranko Gacesa & Arnau Vich Vila & Siobhan Brushett & Marloes Kruk & Jackie Deken, 2024. "Transmission and dynamics of mother-infant gut viruses during pregnancy and early life," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Bo Yuan & Shulei Wang, 2025. "Microbiome data integration via shared dictionary learning," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    9. Natsuko Tabata & Mai Tsukada & Kozue Kubo & Yuri Inoue & Reiko Miroku & Fumihiko Odashima & Koichiro Shiratori & Takashi Sekiya & Shintaro Sengoku & Hideaki Shiroyama & Hiromichi Kimura, 2022. "Living Lab for Citizens’ Wellness: A Case of Maintaining and Improving a Healthy Diet under the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(3), pages 1-17, January.
    10. Gertrude Ecklu-Mensah & Candice Choo-Kang & Maria Gjerstad Maseng & Sonya Donato & Pascal Bovet & Bharathi Viswanathan & Kweku Bedu-Addo & Jacob Plange-Rhule & Prince Oti Boateng & Terrence E. Forrest, 2023. "Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Tetyana Zakharkina & Elke Heinzel & Rembert A Koczulla & Timm Greulich & Katharina Rentz & Josch K Pauling & Jan Baumbach & Mathias Herrmann & Christiane Grünewald & Hendrik Dienemann & Lutz von Mülle, 2013. "Analysis of the Airway Microbiota of Healthy Individuals and Patients with Chronic Obstructive Pulmonary Disease by T-RFLP and Clone Sequencing," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-11, July.
    12. Silvia Rodrigues Jardim & Lucila Marieta Perrotta de Souza & Heitor Siffert Pereira de Souza, 2023. "The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?," IJERPH, MDPI, vol. 20(4), pages 1-23, February.
    13. Juan Salazar & Pablo Durán & María P. Díaz & Maricarmen Chacín & Raquel Santeliz & Edgardo Mengual & Emma Gutiérrez & Xavier León & Andrea Díaz & Marycarlota Bernal & Daniel Escalona & Luis Alberto Pa, 2023. "Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator," IJERPH, MDPI, vol. 20(10), pages 1-24, May.
    14. Benjamin Valderrama & Paulina Calderón-Romero & Thomaz F. S. Bastiaanssen & Aonghus Lavelle & Gerard Clarke & John F. Cryan, 2025. "The South American MicroBiome Archive (saMBA): enriching the microbiome field by studying neglected populations," Nature Communications, Nature, vol. 16(1), pages 1-9, December.
    15. Aibo Gao & Junlei Su & Ruixin Liu & Shaoqian Zhao & Wen Li & Xiaoqiang Xu & Danjie Li & Juan Shi & Bin Gu & Juan Zhang & Qi Li & Xiaolin Wang & Yifei Zhang & Yu Xu & Jieli Lu & Guang Ning & Jie Hong &, 2021. "Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    16. Bin Zhu & David J. Edwards & Katherine M. Spaine & Laahirie Edupuganti & Andrey Matveyev & Myrna G. Serrano & Gregory A. Buck, 2024. "The association of maternal factors with the neonatal microbiota and health," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    17. Lena Takayasu & Wataru Suda & Eiichiro Watanabe & Shinji Fukuda & Kageyasu Takanashi & Hiroshi Ohno & Misako Takayasu & Hideki Takayasu & Masahira Hattori, 2017. "A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-20, August.
    18. Ogochukwu Ofordile & Dora I. A. Pereira & Andrew M. Prentice & Josef Wagner, 2025. "Gut Prevotella stercorea associates with protection against infection in rural African children," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    19. Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    20. Emidio Scarpellini & Emanuele Rinninella & Martina Basilico & Esther Colomier & Carlo Rasetti & Tiziana Larussa & Pierangelo Santori & Ludovico Abenavoli, 2021. "From Pre- and Probiotics to Post-Biotics: A Narrative Review," IJERPH, MDPI, vol. 19(1), pages 1-14, December.

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:epw:ejbio0:v:3:y:2022:i:1:id:17321. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Support Team (email available below). General contact details of provider: https://eu-opensci.org/index.php/ejbio .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.