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Impact of Menopausal Hormonal Therapy on Anti-SARS-Cov-2 Antibody Titers in Middle-Aged Women

Author

Listed:
  • Kiyomitsu Miyachi

    (Tsurumi West Menopause and Rheumatology Clinic, Japan)

  • Kayoko Yamamoto

    (Yokohama Soei University, Faculty of Nursing, Japan)

  • Belinda Sasse

    (MonashHealth, Department of Oncology, Australia)

  • Kazuhito Murata

    (Health Sciences Research Institute, First Diagnostic Division, Japan)

  • Akiko Ihara

    (Keigu Clinic, Diabetes and Women’s Health, Japan)

  • Takao Koyama

    (Koyama Takao Clinic, Japan)

Abstract

Aim: Postmenopausal women often contract the common cold. Following treatment with HRT, symptoms resolve in some women. We hypothesize menopausal hormone therapy (MHT) may increase anti-SARS-Cov-2 IgG antibody titers, leading to greater resilience against COVID-19 infection. Methods: 219 patients were enrolled. Anti-SARS-Cov-2 IgG antibody titers were measured, and the number of days since the second SARS-Cov-2 vaccination was recorded. Linear regression analysis was performed to examine the relationship between these two variables for patients receiving MHT, patients with rheumatoid arthritis (RA) receiving methotrexate and non-MHT/non-RA (NMR). Analysis was further divided into groups aged 60. Results: Anti-SARS-Cov-2 IgG antibody titers in the MHT group were significantly higher than NMR aged >50 (p 60 (p 50. This may confer additional protection against SARS-Cov-2 infection. Women with RA on methotrexate over 60 have lower antibody titers than NMR aged >60.

Suggested Citation

  • Kiyomitsu Miyachi & Kayoko Yamamoto & Belinda Sasse & Kazuhito Murata & Akiko Ihara & Takao Koyama, 2024. "Impact of Menopausal Hormonal Therapy on Anti-SARS-Cov-2 Antibody Titers in Middle-Aged Women," European Journal of Clinical Medicine, European Open Science, vol. 5(2), pages 1-7, March.
    • Handle: RePEc:epw:clinic:v:5:y:2024:i:2:id:12332
    DOI: 10.24018/clinicmed.2024.5.2.332
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