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Contribution of the Leukocyte Adherence Inhibition Test for the Evaluation of Immunoreactivity against Gluten Extracts in Non—IgE-Mediated / Non-Autoimmune Gluten-Related Disorders

Author

Listed:
  • Celso Eduardo Olivier

    (Instituto Alergoimuno de Americana, Brasil)

  • Daiana G. Pinto

    (Instituto Alergoimuno de Americana, Brasil)

  • Ana P. M. Teixeira

    (Instituto Alergoimuno de Americana, Brasil)

  • Jhéssica L. S. Santana

    (Instituto Alergoimuno de Americana, Brasil)

  • Raquel A. P. G. Santos

    (Instituto Alergoimuno de Americana, Brasil)

  • Regiane P. S. Lima

    (Instituto Alergoimuno de Americana, Brasil)

Abstract

Background: The Non-Celiac Gluten Sensitivity (NCGS) is a category inside the Gluten-Related Disorders (GRD) that groups the patients with unidentified mechanisms responsible for their symptoms. Objective: To evaluate the opportunity of an ex vivo challenge immunoassay, the Leukocyte Adherence Inhibition Test (LAIT), to discriminate non—IgE-mediated gluten-specific immunoreactivity in patients with NCGS. Methods: Ex vivo challenge tests performed with gluten latex extract, monitored by LAIT, were assayed in an asymptomatic control group of 30 individuals and a group of 52 patients with GRD not related to any identifiable immune mechanism (NCGS). Results: The mean Leukocyte Adherence Inhibition (LAI) of the control group was 10.9%. The mean LAI of the NCGS patients’ group was 54.9%. The non-parametric Wilcoxon-Mann-Whitney U test comparing the control group with the NCGS patient’s group showed significance with a p-value

Suggested Citation

  • Celso Eduardo Olivier & Daiana G. Pinto & Ana P. M. Teixeira & Jhéssica L. S. Santana & Raquel A. P. G. Santos & Regiane P. S. Lima, 2022. "Contribution of the Leukocyte Adherence Inhibition Test for the Evaluation of Immunoreactivity against Gluten Extracts in Non—IgE-Mediated / Non-Autoimmune Gluten-Related Disorders," European Journal of Clinical Medicine, European Open Science, vol. 3(2), pages 1-7, March.
    • Handle: RePEc:epw:clinic:v:3:y:2022:i:2:id:12175
    DOI: 10.24018/clinicmed.2022.3.2.175
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