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Contribution of the Leukocyte Adherence Inhibition Test to the Evaluation of Cellular Immunoreactivity against Latex Extracts for Non—IgE-Mediated Latex-Fruit-Pollen Syndrome in Allergic Candidates to Exclusion Diets and Allergic Desensitization

Author

Listed:
  • Celso Eduardo Olivier

    (Instituto Alergoimuno de Americana, Brasil)

  • Daiana G. Pinto

    (Instituto Alergoimuno de Americana, Brasil)

  • Ana P. M. Teixeira

    (Instituto Alergoimuno de Americana, Brasil)

  • Jhéssica L. S. Santana

    (Instituto Alergoimuno de Americana, Brasil)

  • Raquel A. P. G. Santos

    (Instituto Alergoimuno de Americana, Brasil)

  • Regiane P. S. Lima

    (Instituto Alergoimuno de Americana, Brasil)

Abstract

Background: Due to the lack of standardized laboratory procedures able to demonstrate specific non—IgE-mediated immune responses against latex allergens, these conditions are diagnosed mostly by clinical criteria based on empiric exclusion prescriptions monitored by in vivo challenge tests. Objective: To evaluate the opportunity of an ex vivo challenge immunoassay, the Leukocyte Adherence Inhibition (LAI) Test (LAIT), to discriminate non—IgE-mediated latex-specific immunoreactivity. Methods: Ex vivo challenge tests performed with Hevea Brasiliense’s latex extract, monitored by LAIT, were assayed in an asymptomatic control group and a group of patients with diverse respiratory and cutaneous non—IgE-mediated allergic conditions, clinically diagnosed by a certified allergologist. Results: The mean LAI of the control group was 8.3%. The mean LAI of the complete patients’ group was 41.1%. The non-parametric Wilcoxon-Mann-Whitney U (WMWU) test comparing the control group with the whole patient’s group showed significance with a p-value

Suggested Citation

  • Celso Eduardo Olivier & Daiana G. Pinto & Ana P. M. Teixeira & Jhéssica L. S. Santana & Raquel A. P. G. Santos & Regiane P. S. Lima, 2022. "Contribution of the Leukocyte Adherence Inhibition Test to the Evaluation of Cellular Immunoreactivity against Latex Extracts for Non—IgE-Mediated Latex-Fruit-Pollen Syndrome in Allergic Candidates to Exclusion Diets and Allergic Desensitization," European Journal of Clinical Medicine, European Open Science, vol. 3(1), pages 11-17, January.
    • Handle: RePEc:epw:clinic:v:3:y:2022:i:1:id:12160
    DOI: 10.24018/clinicmed.2022.3.1.160
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