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Determination of Dynamic Plasma Thiol -disulfide Homeostasis with a Novel Technique in Intestinal Ischemia Reperfusion Injury

Author

Listed:
  • Ersin Gürkan Dumlu

    (Yıldırım Beyazıt University, Turkey)

  • Mehmet Tokaç

    (İstinye University, Turkey)

  • Mustafa Özsoy

    (Yıldırım Beyazıt University, Turkey)

  • İbrahim Kılınç

    (Atatürk Bilkent City Hospital, Turkey)

  • Nazmiye Dinçer

    (Yıldırım Beyazıt University, Turkey)

  • Özcan Erel

    (Yıldırım Beyazıt University, Turkey)

  • Mehmet Kılıç

    (Yıldırım Beyazıt University, Turkey)

Abstract

Introduction: Intestinal ischemia/reperfusion (I/R) is a serious life-threatening clinical case. Overproduction of reactive oxygen species (ROS) associated with oxidative stress plays a key role in I/R pathophysiology. Objective: The aim of this study is to evaluate dynamic thiol / disulfide hemostasis in intestinal I/R in rats. Materials and Methods: 24 Winstar albino rats were divided into 3 groups (8 animals in each group: (1) sham (operation without ischemia), (2) ischemia (90 minutes ischemia), (3) ischemia/reperfusion (after ischemia for 30 minutes reperfusion for 60 minutes). At the end of the process, liver samples were evaluated pathologically. Also, in plasma samples, native thiol, disulphide and total thiol levels were measured. Results: Native thiol levels in ischemia and I/R group were found to be significantly lower compared to the sham group (P

Suggested Citation

  • Ersin Gürkan Dumlu & Mehmet Tokaç & Mustafa Özsoy & İbrahim Kılınç & Nazmiye Dinçer & Özcan Erel & Mehmet Kılıç, 2021. "Determination of Dynamic Plasma Thiol -disulfide Homeostasis with a Novel Technique in Intestinal Ischemia Reperfusion Injury," European Journal of Clinical Medicine, European Open Science, vol. 2(3), pages 55-59, June.
    • Handle: RePEc:epw:clinic:v:2:y:2021:i:3:id:12083
    DOI: 10.24018/clinicmed.2021.2.3.83
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