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Aptamers and SELEX: the technology

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  • Sampson, Tim

Abstract

DNA and RNA microarrays have become an important analytical technique in the understanding and characterisation of genomes and transcriptomes. A recent development in this field of combinatorial chemistry has concentrated on using artificial DNA/RNA sequences--aptamers--as the screening ligand. In reviewing this technology, the article covers the topic, following a general introduction, under the headings: generating an aptamer library, aptamer library complexity, aspects of nucleotide chemistry, constant region primer design, and the SELEX protocol for exposing an aptamer library to the desired target.

Suggested Citation

  • Sampson, Tim, 2003. "Aptamers and SELEX: the technology," World Patent Information, Elsevier, vol. 25(2), pages 123-129, June.
    • Handle: RePEc:eee:worpat:v:25:y:2003:i:2:p:123-129
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