The use of historical control information in modelling dose response relationships in carcinogenesis
An empirical Bayes approach is proposed as a means of utilizing historical control information in modelling the relationship between the level of exposure to the test agent and the rate of tumour occurrence in carcinogenicity bioassays. Using a simple two-parameter linear logistic model, it is shown that when the historical control response rates are tightly clustered around the response rate in the concurrent control group, the empirical Bayes estimator can be considerably more precise than the usual maximum likelihood estimator ignoring the historical data. Efficiency gains were also noted with respect to estimates of quantiles of the dose response curve such as the ED10. With a three-parameter logistic model in which spontaneously occurring lesions are assumed to be stochastically independent of those caused by the test agent, only modest gains in efficiency using historical control data were observed.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 4 (1986)
Issue (Month): 2 (March)
|Contact details of provider:|| Web page: http://www.elsevier.com/wps/find/journaldescription.cws_home/622892/description#description|
|Order Information:|| Postal: http://www.elsevier.com/wps/find/supportfaq.cws_home/regional|
When requesting a correction, please mention this item's handle: RePEc:eee:stapro:v:4:y:1986:i:2:p:87-93. See general information about how to correct material in RePEc.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei)
If references are entirely missing, you can add them using this form.