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Statistical study of asymmetry in cell lineage data

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  • de Saporta, Benoîte
  • Gégout-Petit, Anne
  • Marsalle, Laurence

Abstract

A rigorous methodology is proposed to study cell division data consisting in several observed genealogical trees of possibly different shapes. The procedure takes into account missing observations, data from different trees, as well as the dependence structure within genealogical trees. Its main new feature is the joint use of all available information from several data sets instead of single data set estimation, to avoid the drawbacks of low accuracy for estimators or low power for tests on small single trees. The data is modeled by an asymmetric bifurcating autoregressive process and possibly missing observations are taken into account by modeling the genealogies with a two-type Galton–Watson process. Least-squares estimators of the unknown parameters of the processes are given and symmetry tests are derived. Results are applied on real data of Escherichia coli division and an empirical study of the convergence rates of the estimators and power of the tests is conducted on simulated data.

Suggested Citation

  • de Saporta, Benoîte & Gégout-Petit, Anne & Marsalle, Laurence, 2014. "Statistical study of asymmetry in cell lineage data," Computational Statistics & Data Analysis, Elsevier, vol. 69(C), pages 15-39.
    • Handle: RePEc:eee:csdana:v:69:y:2014:i:c:p:15-39
    DOI: 10.1016/j.csda.2013.07.025
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    References listed on IDEAS

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    1. de Saporta, Benoîte & Gégout-Petit, Anne & Marsalle, Laurence, 2012. "Asymmetry tests for bifurcating auto-regressive processes with missing data," Statistics & Probability Letters, Elsevier, vol. 82(7), pages 1439-1444.
    2. J. Zhou & I. V. Basawa, 2005. "Maximum Likelihood Estimation for a First‐Order Bifurcating Autoregressive Process with Exponential Errors," Journal of Time Series Analysis, Wiley Blackwell, vol. 26(6), pages 825-842, November.
    3. Delmas, Jean-François & Marsalle, Laurence, 2010. "Detection of cellular aging in a Galton-Watson process," Stochastic Processes and their Applications, Elsevier, vol. 120(12), pages 2495-2519, December.
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    Cited by:

    1. Bercu, Bernard & Blandin, Vassili, 2015. "A Rademacher–Menchov approach for random coefficient bifurcating autoregressive processes," Stochastic Processes and their Applications, Elsevier, vol. 125(4), pages 1218-1243.
    2. S. Valère Bitseki Penda & Adélaïde Olivier, 2017. "Autoregressive functions estimation in nonlinear bifurcating autoregressive models," Statistical Inference for Stochastic Processes, Springer, vol. 20(2), pages 179-210, July.
    3. Bernard Bercu & Vassili Blandin, 2015. "Limit theorems for bifurcating integer-valued autoregressive processes," Statistical Inference for Stochastic Processes, Springer, vol. 18(1), pages 33-67, April.
    4. Damien G Hicks & Terence P Speed & Mohammed Yassin & Sarah M Russell, 2019. "Maps of variability in cell lineage trees," PLOS Computational Biology, Public Library of Science, vol. 15(2), pages 1-32, February.
    5. Vincent Bansaye & S. Valère Bitseki Penda, 2021. "A Phase Transition for Large Values of Bifurcating Autoregressive Models," Journal of Theoretical Probability, Springer, vol. 34(4), pages 2081-2116, December.

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