Skin cancer prevention: a systematic review of the efficacy of clinical trial-based interventions

Skin cancer is one of the most common malignancies and its incidence continues to increase worldwide, especially in areas of high ultraviolet (UV) radiation. This systematic review highlights that an effective preventive approach combines sun protection, education, and workplace policies. Advanced sunscreens with DNA repair complexes are useful in reducing precursor lesions such as actinic keratosis. The implementation of workplace policies that provide protective equipment and create shaded areas is especially effective for outdoor workers. Educational programs in schools and on-the-job training encourage sun protection practices from childhood and in work settings, although their effectiveness depends on demographic and cultural factors. It is recommended to tailor interventions to each population and explore their long-term sustainability, as well as to evaluate the economic impact of these policies to achieve effective skin cancer prevention.