Efficacy of Platelet-Rich Plasma in the Treatment of Rotator Cuff Injuries

Background: Rotator cuff injuries are a common cause of shoulder pain and functional limitation. Recently, platelet-rich plasma (PRP) has been proposed as a regenerative therapy to potentially accelerate tendon healing and improve outcomes. Material and methods: We performed a review of studies published between 2010 and 2024 examining the effectiveness of PRP in patients with rotator cuff tendinopathies or partial tears. Clinical trials, observational studies, and meta-analyses were included, focusing on pain reduction (Visual Analogue Scale) and functional improvement (Constant-Murley, Quick DASH). Results: Most studies reported a significant decrease in pain and an improvement in shoulder function after PRP application, especially in patients who did not respond to conventional treatments. No severe adverse effects were identified, although the efficacy varied depending on the concentration of platelets and injection protocols. Conclusion: PRP appears to be a promising option for enhancing tendon healing and reducing pain in rotator cuff injuries. However, the lack of standardized protocols calls for further research to establish definitive guidelines and confirm its long-term benefits and safety.