Acquired Hemophilia during Pregnancy and Postpartum

Hemophilia is a genetic disease that affects blood coagulation. Acquired hemophilia A is an autoimmune-mediated bleeding disorder in which antibodies against coagulation factor VIII develop. It presents during pregnancy and the postpartum period as a cause of obstetric hemorrhage. A literature review was conducted to characterize hemophilia acquired during pregnancy and the postpartum period. Journals and websites from sites such as SciELO were used, yielding a total of 21 references, with a 76.1% update rate. The disease is characterized by severe bleeding and extensive bruising of the trunk and extremities. Hormonal changes during pregnancy significantly alter the balance of hemostasis, leading to hypercoagulability secondary to an inflammatory state. The clinical picture of acquired hemophilia associated with pregnancy has certain characteristics that require study, as it does during the postpartum period.