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Genetic Native American ancestry is associated with a low likelihood of VDR rs7975232 risk genotypes for vitamin D levels

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Listed:
  • Sergio V. Flores
  • Angel Roco-Videla
  • Román M. Montaña
  • Marcela Caviedes-Olmos
  • Sofia Pérez-Jiménez
  • Raúl Aguilera Eguía

Abstract

Introduction: Obesity is associated with chronic diseases, with women being more prone, possibly due to the relationship between the α-estrogen receptor and vitamin D receptors. Objective: The objective of this research is to analyze the distribution of VDR rs7975232 (ApaI) genotypes in Latin American populations and its relationship with genetic ancestry. Methods: 446 SNPs from an AIMs panel were used to estimate genetic ancestry proportions in individuals from Peru, Mexico, Colombia, and Puerto Rico using STRUCTURE software. Kruskal-Wallis, Mann-Whitney tests and logistic regression were applied for analyses. Results: Risk genotypes AA and CA show a low proportion of Native American ancestry and a high proportion of European and African ancestry. Logistic regression indicated an inverse effect of Native American ancestry on risk genotypes. Conclusion: The results suggest that Native American ancestry decreases the likelihood of carrying VDR rs7975232 risk genotypes. These findings contribute to a better understanding of genetic variability and its relationship with health conditions in these populations.

Suggested Citation

Handle: RePEc:dbk:datame:v:3:y:2024:i::p:.379:id:1056294dm2024379
DOI: 10.56294/dm2024.379
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